Results 41 to 50 of about 990,733 (166)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Prepulse inhibition task.

, 2013
Graphical representation of the indexes related to response latency (Resp Lat), maximum peak latency (Peak Lat), maximum peak value (Max Peak), and area (Resp Area) of the responses shown by wild-type (WT) and TgIE96 (TG) groups during a prepulse ...
Etsuro Ono (362648), Masami Morimatsu (128435), Kinuyo Ozaki (362646), Juan C. López-Ramos (362640), Yukiko Tomioka (362642), José M. Delgado-García (106121), Sayo Yamamoto (362644)   +6 more
core   +1 more source

Investigating the Feasibility of Gap Prepulse Inhibition by Auditory Middle Latency Responses in Healthy Subjects

Auditory and Vestibular Research
Background and Aim: Gap Prepulse Inhibition (GPI) is a type of Prepulse Inhibition (PPI) in which a gap is used as a prepulse. This study was conducted to investigate the silence gap effect on Auditory Middle Latency Response (AMLR) inhibition in normal
Hossein Seraji, Ghassem Mohammadkhani, Mohamad Reza Afzalzadeh   +2 more
doaj   +1 more source

The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid, Aiman Saleh A. Mohammed, Gábor Mohácsi, Benjámin Paskuj, Gergő Bitay, Jakub Tomek, Sahil Dalal, Tamás Árpádffy‐Lovas, Vivien Demeter‐Haludka, István Koncz, Muhammad Naveed, László Virág, Norbert Nagy, András Varró, István Baczkó, Norbert Jost, Zsófia Kohajda, Leila Topal   +17 more
wiley   +1 more source

Neurodevelopmental animal models of schizophrenia: Effects on prepulse inhibition

, 2003
Epidemiological studies have shown increased incidence of schizophrenia in patients subjected to different forms of pre- or perinatal stress. However, as the onset of schizophrenic illness does not usually occur until adolescence or early adulthood, it ...
Garner, B., Koch, M., van den Buuse, M.
core   +1 more source

Lymphatic Abnormalities in Noonan Syndrome Extend Beyond Clinically Apparent Disease

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2211-2223, October 2026.
ABSTRACT Lymphatic disease represents a well‐described manifestation of Noonan syndrome (NS), yet the full phenotypic spectrum remains incompletely characterized, especially in asymptomatic individuals. We conducted a cross‐sectional study including 10 individuals with NS (four with peripheral lymphedema and six without) and 10 age‐ and sex‐matched ...
Inger Norlyk Sheyanth, Benjamin Kelly, Sheyanth Mohanakumar, Steffen Ringgaard, Yoav Dori, Irene Kibæk Nielsen, Uffe Birk Jensen, Vibeke Elisabeth Hjortdal   +7 more
wiley   +1 more source

Sex differences in prepulse inhibition of the acoustic startle response

, 2003
The startle response is inhibited when the startle-eliciting stimulus is preceded 30-500 ms by a prepulse. This effect, known as prepulse inhibition (PPI), is believed to represent a sensorimotor gating mechanism, which protects the brain from ...
Selina Luscher, Payal Gupta, Luscher, S, Kumari, V, Gray, J A, Gupta, P, Jeffrey A Gray, Tonmoy Sharma, Sharma, T, Veena Kumari   +9 more
core   +1 more source

Maternal and Postnatal Effects of Poly I:C‐Induced Intrauterine Inflammation and Rytvela, a Non‐Competitive IL‐1R Antagonist, in the Pregnant Spiny Mouse

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Maternal infection‐induced inflammation during pregnancy is associated with adverse neurodevelopment. Rytvela, an allosteric IL‐1 receptor antagonist, reduces IL‐1β‐mediated pathology in fetal rodents and sheep. However, its effects on TLR3‐mediated inflammation and subsequent offspring growth and behavior remain unclear. Using precocial spiny
Nhi T. Tran, Rachid Kamareddine, Nadia Bellofiore, David M. Olson, Sylvain Chemtob, Sarah A. Robertson, Jeffrey A. Keelan, Stacey J. Ellery   +7 more
wiley   +1 more source

Distinct forms of prepulse inhibition disruption distinguishable by the associated changes in prepulse-elicited reaction.

, 2009
Prepulse inhibition (PPI) of the acoustic startle reflex has been extensively employed as a test of sensorimotor gating or early attentional control in neuropsychiatric research, because a number of psychiatric conditions, including schizophrenia ...
Feldon J, Yee BK
core   +1 more source

Pressure‐Induced Changes in Intracellular pH Facilitate the Myogenic Response of Rat Small Tail Arteries

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim The myogenic response contributes considerably to blood flow autoregulation. Intracellular pH (pHi) has a substantial impact on small artery contractility. However, the role of putative pHi changes during myogenic constriction is unknown.
Ulrike Krien, Rudolf Schubert
wiley   +1 more source