Results 21 to 30 of about 12,508 (203)
Assessing Prepulse Inhibition of Startle in Mice
Bio-Protocol, 2018 Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia.
Christina Ioannidou +2 more
doaj +4 more sources
The role of hippocampal dopamine receptors in prepulse inhibition.
European Journal of Neuroscience, 2002 Item does not contain fulltextAlthough it has long been realized that the hippocampal formation receives a projection from the midbrain dopaminergic cell groups and contains mRNA for all five dopamine receptors, the functional role of this dopaminergic ...
Cools, A.R. +2 more
core +5 more sources
The Eletrophysiology of Prepulse Inhibition
, 2015 The acoustic startle response is decreased by a prepulse occurring 30-500 ms earlier. This prepulse inhibition (PPI) is interpreted in terms of the Interruption and Protection hypotheses, in which startle responding interrupts prepulse processing ...
Schächinger, Hartmut +3 more
core +2 more sources
Neuropsychopharmacology ReportsGPR143, originally identified as the gene product of ocular albinism 1 (OA1), a G protein‐coupled receptor (GPCR), can function as a receptor for l‐3,4‐dihydroxyphenylalanine (DOPA), a precursor of dopamine (DA).
Yoshio Goshima +9 more
doaj +2 more sources
Neuropsychopharmacology Reports, 2021 Genetic and environmental factors interact with each other to influence the risk of various psychiatric diseases; however, the intensity and nature of their interactions remain to be elucidated.
Yutaro Kobayashi +7 more
doaj +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
The Effects of Memantine on Prepulse Inhibition [PDF]
Neuropsychopharmacology, 2009 Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the effects of NMDA antagonists on PPI.
Swerdlow, NR +4 more
openaire +4 more sources
Contrasting effect of prepulse signals on performance of Toxoplasma-infected and Toxoplasma-free subjects in an acoustic reaction times test. [PDF]
PLoS ONE, 2014 About 30% of people on Earth have latent toxoplasmosis. Infected subjects do not express any clinical symptoms, however, they carry dormant stages of parasite Toxoplasma for the rest of their life. This form of toxoplasmosis is mostly considered harmless,
Lenka Příplatová +2 more
doaj +1 more source
Nicotine Effect on Prepulse Inhibition and Prepulse Facilitation in Schizophrenia Patients [PDF]
Neuropsychopharmacology, 2007 Acoustic prepulse inhibition (PPI) is considered an important biomarker in animal studies of psychosis and a number of psychiatric conditions. Nicotine has been shown to improve acoustic PPI in some animal strains and in humans. However, there is little data on effects of nicotine on acoustic PPI in schizophrenia patients using a double-blind, placebo ...
L Elliot, Hong +3 more
openaire +2 more sources
Interaural delay modulates the prepulse inhibition of the startle reflex induced by binaural gap in humans [PDF]
JASA Express Letters, 2021 This study used prepulse inhibition (PPI) of the acoustic startle reflex as a physiological measure to determine the sensitivity to a break in interaural correlation (BIC) in binaural gap detection and compared this physiological measure with the ...
Ming Lei, Yu Ding
doaj +1 more source