Results 21 to 30 of about 990,733 (166)

Prepulse inhibition of the acoustic startle reflex in high functioning autism. [PDF]

PLoS ONE, 2014
BACKGROUND: High functioning autism is an autism spectrum disorder that is characterized by deficits in social interaction and communication as well as repetitive and restrictive behavior while intelligence and general cognitive functioning are preserved.
Sina Kohl, Carolin Wolters, Theo O J Gruendler, Kai Vogeley, Joachim Klosterkötter, Jens Kuhn   +5 more
doaj   +1 more source

The Effects of Attention on the Syllable-Induced Prepulse Inhibition of the Startle Reflex and Cortical EEG Responses against Energetic or Informational Masking in Humans

Brain Sciences, 2022
Prepulse inhibition (PPI) is the reduction in the acoustic startle reflex (ASR) when the startling stimulus (pulse) is preceded by a weaker, non-starting stimulus.
Xiaoqin Yang, Lei Liu, Pengcheng Yang, Yu Ding, Changming Wang, Liang Li   +5 more
doaj   +1 more source

GABAB Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat

Frontiers in Integrative Neuroscience, 2021
Altered sensory information processing, and auditory processing, in particular, is a common impairment in individuals with autism spectrum disorder (ASD).
Dorit Möhrle, Wenxuan Wang, Shawn N. Whitehead, Susanne Schmid   +3 more
doaj   +1 more source

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Journal of Pharmacological Sciences, 2012
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda   +10 more
doaj   +1 more source

Expression of catecholaminergic genes in the midbrain and prepulse inhibition in rats with a genetic catatonia

Вавиловский журнал генетики и селекции, 2017
The GC rat strain (from the words “genetic” and “catatonia”) was created by selection for predisposition to passive-defensive reaction of catatonic freezing in response to stressing stimuli.
M. A. Ryazanova, O. I. Prokudina, V. S.  Plekanchuk, T. A. Alekhina   +3 more
doaj   +1 more source

Effects of stimulus-driven and goal-directed attention on prepulse inhibition of brain oscillations

Frontiers in Human Neuroscience, 2016
Objective: Prepulse inhibition (PPI) is an operational measure of sensory gating. PPI of cortical response to a startling pulse is known to be modulated by attention.
Agnes Annic, Agnes Annic, Jean-Louis Bourriez, Arnaud Delval, Arnaud Delval, Perrine Bocquillon, Perrine Bocquillon, Claire Trubert, Philippe Derambure, Philippe Derambure, Kathy Dujardin, Kathy Dujardin   +11 more
doaj   +1 more source

Prepulse inhibition of startle.

, 2013
Behavioral tests in mouse exposed to maternal immune activation at gestation day 9 or 17 (GD9 POL; GD17 POL) compared to controls (CON). Prepulse inhibition of startle (PPI). % PPI =  (pulse-alone - prepulse-plus-pulse)/pulse-alone×100%.
Sookja Chung (261115), Ed X. Wu (285920), Urs Meyer (356164), Qi Li (67548), Edward S. Hui (371469), Siew E. Chua (350156), Grainne M. McAlonan (285918), Ran Wei (295560), Pak C. Sham (58020), Charlton Cheung (350151), Joram Feldon (356165)   +10 more
core   +1 more source

Maternal separation followed by isolation-housing differentially affects prepulse inhibition of the acoustic startle response in C57BL/6 mice [PDF]

, 2016
Exposure to chronic stress is associated with an increased incidence of neuropsychiatric dysfunction. The current study evaluated two competing hypotheses, the cumulative stress and the match/mismatch hypothesis of neuropsychiatric dysfunction, using two
Garza, Xavier J, Jordan, Richard L, Bailoo, Jeremy Davidson, Hintze, Sara, Varholick, Justin Adam   +4 more
core   +3 more sources

Prepulse inhibition in Drosophila melanogaster larvae

Biology Open, 2018
The neural mechanisms of psychiatric diseases like autism spectrum disorder and schizophrenia have been intensively studied, and a number of candidate genes have been identified.
Yutaro Matsumoto, Kazuya Shimizu, Kota Arahata, Miku Suzuki, Akira Shimizu, Koki Takei, Junji Yamauchi, Satoko Hakeda-Suzuki, Takashi Suzuki, Takako Morimoto   +9 more
doaj   +1 more source

A QTL on rat chromosome 7 modulates prepulse inhibition, a neuro-behavioral trait of ADHD, in a Lewis x SHR intercross

Behavioral and Brain Functions, 2006
Background Attention deficit hyperactivity disorder (ADHD) is a complex neuropsychiatric disorder with a substantial genetic component. The Spontaneously Hypertensive Rats (SHR), considered as a good animal model of ADHD, also show less anxiety-like ...
Ramos André, Raba Frantz, Terenina-Rigaldie Elena, Vendruscolo Leandro, Takahashi Reinaldo, Mormède Pierre   +5 more
doaj   +1 more source