Prepulse inhibition of acoustic startle reflex as a function of the frequency difference between prepulse and background sounds in mice. [PDF]
PLoS ONE, 2012 Prepulse inhibition (PPI) depicts the effects of a weak sound preceding strong acoustic stimulus on acoustic startle response (ASR). Previous studies suggest that PPI is influenced by physical parameters of prepulse sound such as intensity and preceding ...
Sidhesh Basavaraj, Jun Yan
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Journal of Parkinson’s Disease, 2014 Background: Prepulse inhibition is a measure of sensorimotor gating, which reflects the ability to filter or ‘gate’ irrelevant information. Prepulse inhibition is dramatically altered in basal ganglia disorders associated with dysfunction in the midbrain
Marielle Zoetmulder +5 more
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Prepulse inhibition of auditory change-related cortical responses [PDF]
BMC Neuroscience, 2012 Background Prepulse inhibition (PPI) of the startle response is an important tool to investigate the biology of schizophrenia. PPI is usually observed by use of a startle reflex such as blinking following an intense sound.
Inui Koji +7 more
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The Effects of Brief Mindfulness Training on Attentional Processes: Mindfulness Increases Prepulse Facilitation but Not Prepulse Inhibition [PDF]
Frontiers in Psychology, 2021 Mindfulness is intentional focus of one’s attention on emotions, thoughts, or sensations occurring in the present moment with a nonjudgmental attitude.
Ole Åsli +2 more
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GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans. [PDF]
PLoS ONE, 2018 Despite their essential roles in signal processing in the brain, the functions of interneurons currently remain unclear in humans. We recently developed a method using the prepulse inhibition of sensory evoked cortical responses for functional ...
Koji Inui +4 more
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TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
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Neuropsychopharmacology Reports, 2021 Genetic and environmental factors interact with each other to influence the risk of various psychiatric diseases; however, the intensity and nature of their interactions remain to be elucidated.
Yutaro Kobayashi +7 more
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Contrasting effect of prepulse signals on performance of Toxoplasma-infected and Toxoplasma-free subjects in an acoustic reaction times test. [PDF]
PLoS ONE, 2014 About 30% of people on Earth have latent toxoplasmosis. Infected subjects do not express any clinical symptoms, however, they carry dormant stages of parasite Toxoplasma for the rest of their life. This form of toxoplasmosis is mostly considered harmless,
Lenka Příplatová +2 more
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Interaural delay modulates the prepulse inhibition of the startle reflex induced by binaural gap in humans [PDF]
JASA Express Letters, 2021 This study used prepulse inhibition (PPI) of the acoustic startle reflex as a physiological measure to determine the sensitivity to a break in interaural correlation (BIC) in binaural gap detection and compared this physiological measure with the ...
Ming Lei, Yu Ding
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Inhibition in the Human Auditory Cortex.
PLoS ONE, 2016 Despite their indispensable roles in sensory processing, little is known about inhibitory interneurons in humans. Inhibitory postsynaptic potentials cannot be recorded non-invasively, at least in a pure form, in humans.
Koji Inui +4 more
doaj +1 more source