Results 51 to 60 of about 990,733 (166)
The role of hippocampal dopamine receptors in prepulse inhibition.
, 2002 Item does not contain fulltextAlthough it has long been realized that the hippocampal formation receives a projection from the midbrain dopaminergic cell groups and contains mRNA for all five dopamine receptors, the functional role of this dopaminergic ...
Cools, A.R. +2 more
core +1 more source
Cocaine strongly reduces prepulse inhibition in apomorphine-susceptible rats, but not in apomorphine-unsusceptible rats: regulation by dopamine D2 receptors. [PDF]
, 2006 Contains fulltext : 50736.pdf (Publisher’s version ) (Closed access)Dopaminergic agonists, such as apomorphine and amphetamine, have been shown to drastically reduce prepulse inhibition of the acoustic startle reflex. The effects of the
Elst, M.C.J. van der +2 more
core +1 more source
Assessing Prepulse Inhibition of Startle in Mice
Bio-Protocol, 2018 Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia.
Christina Ioannidou +2 more
doaj +1 more source
Psychophysiological markers of vulnerability to psychopathology in men with an extra X chromosome (XXY). [PDF]
PLoS ONE, 2011 Studying genetically defined syndromes associated with increased risk for psychopathology may help in understanding neurodevelopmental mechanisms related to risk for psychopathology. Klinefelter syndrome (47,XXY) is one of the most common sex chromosomal
Sophie van Rijn +4 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville +6 more
wiley +1 more source
, 2002 BACKGROUND Prepulse inhibition and latent inhibition are the two animal paradigms currently dominating neuropharmacological research on attentional deficits in schizophrenia. Both paradigms have been shown to have a reasonable amount of face, predictive,
Vollenweider FX +3 more
core +1 more source
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Annexin A4 (A4) inhibits adenylyl cyclase 5 and may protect the heart during chronic β‐adrenergic stress. After 7 days of isoprenaline, A4‐deficient mice showed greater cardiomyocyte hypertrophy, prolonged action potentials, reduced Ito, preserved ICaL with altered activation, increased NCX1, and enhanced acute cAMP responsiveness compared with wild ...
Florentina Pluteanu +4 more
wiley +1 more source
Prepulse Inhibition of the Acoustic Startle Reflex in fbΔBMPRII Mice.
, 2015 The fbΔBMPRII mutants (red) and control littermates (white) showed similar levels of prepulse inhibition of the acoustic startle across three different intensities of the prepulse stimulus.
Jiva Dimova (804560) +6 more
core +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen +11 more
wiley +1 more source
The Eletrophysiology of Prepulse Inhibition
, 2015 The acoustic startle response is decreased by a prepulse occurring 30-500 ms earlier. This prepulse inhibition (PPI) is interpreted in terms of the Interruption and Protection hypotheses, in which startle responding interrupts prepulse processing ...
Schächinger, Hartmut +3 more
core +1 more source