Results 51 to 60 of about 12,508 (203)

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Prepulse reactivity in prepulse inhibition. [PDF]

, 2010
Prepulse inhibition (PPI) is a popular paradigm in sensorimotor gating research. In healthy individuals the weak lead stimulus (i.e., the prepulse) presentation results in a reduction in the startle probe (pulse) elicited response. The motor responses to
Ewa G Truchanowicz
core  

Prepulse inhibition task.

, 2013
Graphical representation of the indexes related to response latency (Resp Lat), maximum peak latency (Peak Lat), maximum peak value (Max Peak), and area (Resp Area) of the responses shown by wild-type (WT) and TgIE96 (TG) groups during a prepulse ...
Etsuro Ono (362648), Masami Morimatsu (128435), Kinuyo Ozaki (362646), Juan C. López-Ramos (362640), Yukiko Tomioka (362642), José M. Delgado-García (106121), Sayo Yamamoto (362644)   +6 more
core   +1 more source

Evidence of Hyperacusis in Adult Rats Following Non-traumatic Sound Exposure

Frontiers in Systems Neuroscience, 2019
Manipulations that enhance neuroplasticity may inadvertently create opportunities for maladaptation. We have previously used passive exposures to non-traumatic white noise to open windows of plasticity in the adult rat auditory cortex and induce ...
Maryse E. Thomas, Maryse E. Thomas, Gerson D. Guercio, Gerson D. Guercio, Kristina M. Drudik, Étienne de Villers-Sidani, Étienne de Villers-Sidani   +6 more
doaj   +1 more source

A Stopped‐Flow Instrument for Millisecond Timescale Reaction Monitoring on a Standard NMR Spectrometer

Magnetic Resonance in Chemistry, EarlyView.
A new stopped‐flow instrument allows kinetic measurements of reactions 10 milliseconds after initiating them by mixing in a flow cell inserted into a standard NMR probe and spectrometer. High‐speed video, pressure and NMR line‐shape data are used to characterise mixing and stopping, and a protodeboronation reaction with a 5‐millisecond half‐life used ...
Andrew M. R. Hall, Edward J. King, Lloyd A. L. Mitchell, George A. Steedman, Stuart Johnstone, Clark Landis, Guy C. Lloyd‐Jones   +6 more
wiley   +1 more source

Neurodevelopmental animal models of schizophrenia: Effects on prepulse inhibition

, 2003
Epidemiological studies have shown increased incidence of schizophrenia in patients subjected to different forms of pre- or perinatal stress. However, as the onset of schizophrenic illness does not usually occur until adolescence or early adulthood, it ...
Garner, B., Koch, M., van den Buuse, M.
core   +1 more source

Motivated attention and prepulse inhibition of startle in rats: Using conditioned reinforcers as prepulses. [PDF]

Behavioral Neuroscience, 2007
In humans, prepulse inhibition (PPI) of startle is greater during attended prestimuli than it is during ignored prestimuli, whereas in rats, most work has focused on passive PPI, which does not require attention. In the work described in this article, researchers developed a paradigm to assess attentional modification of PPI in rats using ...
Joseph S, Baschnagel, Larry W, Hawk, Craig R, Colder, Jerry B, Richards   +3 more
openaire   +2 more sources

Investigating the Feasibility of Gap Prepulse Inhibition by Auditory Middle Latency Responses in Healthy Subjects

Auditory and Vestibular Research
Background and Aim: Gap Prepulse Inhibition (GPI) is a type of Prepulse Inhibition (PPI) in which a gap is used as a prepulse. This study was conducted to investigate the silence gap effect on Auditory Middle Latency Response (AMLR) inhibition in normal
Hossein Seraji, Ghassem Mohammadkhani, Mohamad Reza Afzalzadeh   +2 more
doaj   +1 more source

Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus.

PLoS ONE, 2020
The gap-prepulse inhibition of the acoustic startle reflex has been widely used as a behavioral method for tinnitus screening in animal studies. The cortical-evoked potential gap-induced inhibition has also been investigated in animals as well as in ...
Yunseo Ku, Do Youn Kim, Chiheon Kwon, Tae Soo Noh, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Hee Chan Kim, Myung-Whan Suh   +8 more
doaj   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source