Results 71 to 80 of about 990,733 (166)

Effect of Visuospatial Attention on the Sensorimotor Gating System

Frontiers in Behavioral Neuroscience, 2019
The integration of multiple sensory modalities allows us to adapt to the environment of the outside world. It is widely known that visual stimuli interfere with the processing of auditory information, which is involved in the ability to pay attention ...
Daisuke Ishii, Daisuke Ishii, Kotaro Takeda, Satoshi Yamamoto, Akira Noguchi, Kiyoshige Ishibashi, Kenya Tanamachi, Arito Yozu, Yutaka Kohno   +8 more
doaj   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response

, 2007
Feedforward inhibition deficits have been consistently demonstrated in a range of neuropsychiatric conditions using prepulse inhibition (PPI) of the acoustic startle eye-blink reflex when assessing sensorimotor gating.
Campbell, Linda E., Fulham, W. Ross, Hughes, Matthew, Budd, Timothy W., Stojanov, Wendy, Cooper, Gavin, Johnston, Patrick, Hanlon, Mary-Claire, Karayanidis, Frini, Case, Vanessa, Schall, Ulrich   +10 more
core   +1 more source

BDNF deficiency and young-adult methamphetamine induce sex-specific effects on prepulse inhibition regulation

Frontiers in Cellular Neuroscience, 2013
Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of schizophrenia, yet its role in the development of specific symptoms is unclear. Methamphetamine (METH) users have an increased risk of psychosis and schizophrenia, and
Elizabeth E Manning, Maarten eVan Den Buuse   +1 more
doaj   +1 more source

Physiological and Behavioural Characterisation of a Novel Steroid Sulfatase‐Deficient Mouse

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
STS‐deficient mice are grossly healthy and breed as expected, but are mildly hyperactive and have heavier hearts compared with sex‐matched wildtype controls. ABSTRACT Steroid sulfatase (STS) cleaves sulphate groups from steroid hormones. In humans, STS deficiency is associated with X‐linked ichthyosis, an increased predisposition to neurodevelopmental ...
Trevor Humby, Freya R. Shepherd, Talia Elgie, Libby Anderson‐Watkins, Lucy I. Beevors, Angela E. Taylor, Paul A. Foster, William Davies   +7 more
wiley   +1 more source

Effect of Aripiprazole on 5-HT2Receptor–mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats

Journal of Pharmacological Sciences, 2008
Aripiprazole, an atypical antipsychotic drug, is a D2dopamine–receptor partial agonist, but also has affinity to several serotonin receptors (5-HT1A,2A,2C,7).
Shuntaro Kohnomi, Katsuya Suemaru, Hiromu Kawasaki, Hiroaki Araki   +3 more
doaj   +1 more source

Neuronal subset-specific Pten-deficient mice do not exhibit deficits in sensorimotor gating processes [version 3; peer review: 1 approved, 2 approved with reservations]

F1000Research, 2020
Background: Deficits in sensorimotor gating have been reported in individuals with autism spectrum disorder (ASD), as well as in ASD murine models. However, this behavior has not been examined in the neuronal subset-specific (NS)-Pten knockout (KO) model
Matthew S. Binder, Joaquin N. Lugo, Suzanne O. Nolan   +2 more
doaj   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network

Frontiers in Neural Circuits, 2015
Prepulse inhibition (PPI) is understood as an inhibitory process that attenuates sensory flow during early stages (20-1000ms) of information processing. Here, we applied in vivo electrophysiology and pharmacology to determine if prepulse inhibition (PPI)
Paul C.P. Curtin, Thomas ePreuss
doaj   +1 more source

Acoustic Startle with prepulse inhibition.

, 2013
Startle response was measured following exposure to a 120 dB tone. For prepulse (PP) inhibition, tone was preceded by a softer tone of either 70 or 76 dB.
Michael T. Williams (357796), Joseph F. Clark (103796), Matthew R. Skelton (357788), Charles V. Vorhees (357797), Tori L. Schaefer (357790), Devon L. Graham (357792), Ton J. deGrauw (357794)   +6 more
core   +1 more source