Results 71 to 80 of about 12,508 (203)

Animals models of maladaptive traits: Disorders in sensorimotor gating and attentional quantifiable responses as possible endophenotypes

Frontiers in Psychology, 2016
Traditional diagnostic scales are based on a number of symptoms to evaluate and classify mental diseases. In many cases, this process becomes subjective, since the patient must calibrate the magnitude of his/her symptoms and therefore the severity of his/
Juan Pedro Vargas, Estrella eDiaz, Manuel ePortavella, Juan Carlos López   +3 more
doaj   +1 more source

Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Hydrogen gas inhalation restored antioxidant capacity in a schizophrenia‐like mouse model but did not significantly improve behavioral deficits. These findings suggest that hydrogen may have potential as an adjunct therapy targeting oxidative stress in psychiatric disorders.
Nobumi Miyake, Toshiaki Haga, Shin‐Ichi Hirano, Yusuke Ichikawa, Yoshiyo Oguchi, Kumiko Ando   +5 more
wiley   +1 more source

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

Neurobiology of Disease, 2011
Fragile X syndrome, the most common form of inherited intellectual disability, is caused by a lack of FMRP, which is the product of the Fmr1 gene. FMRP is an RNA-binding protein and a component of RNA-granules found in the dendrites of neurons.
Josien Levenga, Shigemi Hayashi, Femke M.S. de Vrij, Sebastiaan K. Koekkoek, Herma C. van der Linde, Ingeborg Nieuwenhuizen, Cheng Song, Ronald A.M. Buijsen, Andreea S. Pop, Baltazar GomezMancilla, David L. Nelson, Rob Willemsen, Fabrizio Gasparini, Ben A. Oostra   +13 more
doaj   +1 more source

Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Expression of the VIP/PACAP receptor gene, Vipr2, was selectively upregulated in the nucleus accumbens of spontaneous hypertensive rats (SHRs), an animal model of ADHD, with no changes observed in DNA methylation levels at the CpG islands of the gene. This region‐specific overexpression may contribute to ADHD‐related behaviors in SHRs.
Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yabe   +3 more
wiley   +1 more source

Lesions of the dorsomedial striatum disrupt prepulse inhibition [PDF]

Neuroscience, 2011
Prepulse inhibition (PPI) of startle is an experimentally tractable measure of sensorimotor gating that can be readily evaluated in mice, rats, monkeys, and humans. PPI is the inhibitory effect of a low-intensity stimulus, the prepulse, on the startle response to a subsequent high-intensity stimulus.
L C, Baldan Ramsey, M, Xu, N, Wood, C, Pittenger   +3 more
openaire   +2 more sources

What Is the StartReact Effect?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT The use of a startling acoustic stimulus during a simple reaction time task results in the rapid initiation of a prepared response at extremely short latencies (< 80 ms). This so‐called “StartReact effect” has been increasingly employed to probe subcortical contributions to response preparation, as it is thought to occur due to increased ...
Anthony N. Carlsen, Dana Maslovat
wiley   +1 more source

Interval Timing Is Altered in Male Nrxn1+/− Mice: A Model of Autism Spectrum Disorder

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication, and increased repetitive and stereotypical behavior. Neuroimaging shows functional abnormalities in brain areas involved in temporal processing in autistic individuals, and they also show deficits in interval timing.
Kyle M. Roddick, Elias B. Habib, Richard E. Brown, Fuat Balcı   +3 more
wiley   +1 more source

Prepulse inhibition and genetic mouse models of schizophrenia [PDF]

Behavioural Brain Research, 2009
Mutant mouse models related to schizophrenia have been based primarily on the pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate genes for schizophrenia. Sensorimotor gating deficits in schizophrenia patients, as indexed by measures of prepulse inhibition of startle (PPI), have been well characterized and ...
Susan B, Powell, Xianjin, Zhou, Mark A, Geyer   +2 more
openaire   +2 more sources

Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning

Journal of Pharmacological Sciences, 2010
.: Hyper-signaling of the epidermal growth factor receptor family (ErbB) is implicated in the pathophysiology of schizophrenia. Various quinazoline inhibitors targeting ErbB1 or ErbB2 – 4 have been developed as anti-cancer agents and might be useful for ...
Makoto Mizuno, Yuriko Iwakura, Masako Shibuya, Yingjun Zheng, Takeyoshi Eda, Taisuke Kato, Yohei Takasu, Hiroyuki Nawa   +7 more
doaj   +1 more source

Towards Mechanism‐Informed Treatments for Mental Health

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence   +27 more
wiley   +1 more source