Results 91 to 100 of about 24,368 (229)

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia.
Keying Chen, Emma Pineau, Margaret Koletar, Andrea Trevisiol, Jack Simiao He, Mary Hill, Maged Goubran, John Sled, JoAnne McLaurin, Bojana Stefanovic   +9 more
wiley   +1 more source

Vulnerability of the locus coeruleus–entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC–entorhinal cortex (LC‐EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).
Elouise A. Koops, Averi Giudicessi, Ana Baena, Lusiana Martinez, Nikole Bonillas‐Felix, Randy Medrano, Joyita Dutta, Isabela Gonzalez, Sergio Alvarez, David Aguillon, Yakeel T. Quiroz, Heidi I. L. Jacobs   +11 more
wiley   +1 more source

Exogenous Aβ1–42 monomers rescue memory deficits in presenilin-1 and presenilin-2 conditional double knockout mice

Brain Research Bulletin
Emerging evidence challenges the direct causal relationship between amyloid-β (Aβ) deposition and cognitive decline in Alzheimer's disease (AD), as exemplified in presenilin-1 and presenilin-2 conditional double knockout (cDKO) mice which exhibit no ...
Jinnan Chen, Bo Wang, Zhidong Chen, Fan Ding, Jiayue Wang, Chaoyang Ding, Xiaohua Cao   +6 more
doaj   +1 more source

Authorship and citation trends in dementia research: A path to equitable career development for scientists

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan, Diana Karamacoska, Lokendra S. Thakur, Mouna Sawan, Angela Gomez‐Arboledas, Ines Moreno‐Gonzalez, C. Elizabeth Shaaban, Sadaf A. Milani, Giedre Milinkeviciute, Samantha M. Loi, Anika Wuestefeld, Sindhuja T. Govindarajan, Audrey Low, Giovanna Carello‐Collar, Hom L. Shreshta, Sunnie Kenowsky, Claudia K. Suemoto, Michelle M. Mielke, Shana D. Stites   +18 more
wiley   +1 more source

Functional Phenotype in Transgenic Mice Expressing Mutant Human Presenilin-1

Neurobiology of Disease, 2000
Mutations in the presenilin-1 (PS1) gene cause approximately 50% of cases of early onset familial Alzheimer's disease. The function of this protein remains unknown.
Paul A. Barrow, Ruth M. Empson, Simon J. Gladwell, Caroline M. Anderson, Richard Killick, Xin Yu, John G.R. Jefferys, Karen Duff   +7 more
doaj   +1 more source

Effect of cold and warm white light on selected endocrine and immune parameters of broiler embryos and hatchlings

Czech Journal of Animal Science, 2020
Lighting conditions during incubation can influence embryonic development, post-hatching ontogeny and production efficiency. Previous studies revealed that different light colours differently affect pineal melatonin biosynthesis in embryos and ...
Angelika Drozdova, Zuzana Kankova, Michal Zeman   +2 more
doaj   +1 more source

Tramiprosate, the Active Agent of ALZ‐801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease

Drug Development Research, Volume 87, Issue 4, June 2026.
ABSTRACT ALZ‐801, a valine‐conjugated prodrug of tramiprosate, has recently been evaluated in a Phase III trial as a potential Alzheimer's disease (AD)‐modifying therapy. Tramiprosate reduces misfolding of amyloid beta (Aβ) monomers and inhibits oligomer formation. In the present study, we investigated tramiprosate's effects on amyloidogenic processing
Kevser Biberoglu, Ozden Tacal
wiley   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

Cell Reports, 2013
Deciphering the mechanism by which the relative Aβ42(43) to total Aβ ratio is regulated is central to understanding Alzheimer disease (AD) etiology; however, the mechanisms underlying changes in the Aβ42(43) ratio caused by familial mutations and γ ...
Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Mako Takami, Takashi S. Kodama, Kohji Mori, Taisuke Nakayama, Yasuo Ihara, Masatoshi Takeda   +8 more
doaj   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source