Results 101 to 110 of about 24,368 (229)
Presenilin 1 is Actively Degraded by the 26S Proteasome
Neurobiology of Aging, 1998 The metabolic pathways governing the turnover of presenilin 1 (PS1) have been incompletely worked out. The PS1 holoprotein has low abundance in many cells and appears to undergo endoproteolytic cleavage near residue 298. We provide evidence that one mechanism by which the PS1 holoprotein is degraded is through the action of the 26S proteasome.
P E, Fraser +9 more
openaire +2 more sources
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto +7 more
wiley +1 more source
Bipolar Disorders, Volume 28, Issue 4, June 2026.ABSTRACT Background Bipolar disorder (BD) is among the most heritable psychiatric disorders, with a genetic architecture likely consisting of both common genetic variants with small effects and rare variants with strong effects in certain families or populations.
Albert H. C. Wong +8 more
wiley +1 more source
The genetics of Alzheimer's disease
Clinical Interventions in Aging, 2014 Eva Bagyinszky,1 Young Chul Youn,2 Seong Soo A An,1,* SangYun Kim3,*1Department of BioNano Technology Gachon University, Gyeonggi-do, 2Department of Neurology, Chung-Ang University College of Medicine, Seoul, 3Department of Neurology, Seoul National ...
Bagyinszky E, Youn YC, An SSA, Kim SY
doaj
Neurobiology of Disease, 2004 To study the role of Aβ amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of PS1 ...
Allal Boutajangout +6 more
doaj +1 more source
Deletion of Robo4 worsens neuroinflammation in a mouse model of Alzheimer's disease
Physiological Reports, Volume 14, Issue 11, June 2026.Abstract Declines in vascular integrity are potential contributors to Alzheimer's disease (AD) as these result in increased blood–brain barrier permeability and, consequently, accelerate neuroinflammation and cognitive impairment. Roundabout guidance receptor 4 (Robo4) is primarily expressed in endothelial cells and stabilizes the vasculature, thereby ...
Abigail E. Cullen +8 more
wiley +1 more source
APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1
Molecular Neurodegeneration, 2007 Background The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD).
Neve Rachael L +5 more
doaj +1 more source
PRESENILIN 1 mutations causing early-onset familial Alzheimer’s disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction [PDF]
, 2021 Karissa Barthelson +3 more
openalex +1 more source
The clinical utility of gene testing for Alzheimer’s disease
Neurology International, 2011 Alzheimer’s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a ...
Emily R. Atkins, Peter K. Panegyres
doaj +1 more source
Presenilin‐1 and intracellular calcium stores regulate neuronal glutamate uptake [PDF]
, 2004 Yaxiong Yang +4 more
openalex +1 more source