Results 111 to 120 of about 24,368 (229)

Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1 [PDF]

, 2008
Donald B. Carter, Edwige Dunn, Adele M. Pauley, Denise D. McKinley, Timothy J. Fleck, Brenda R Ellerbrook, Nancy C. Stratman, Xiangdong Zhou, Carol S. Himes, Jeffrey S. Nye, Alfredo G. Tomasselli, Riqiang Yan   +11 more
openalex   +1 more source

Epigenetic modifications of DNA and RNA in Alzheimer’s disease

Frontiers in Molecular Neuroscience
Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the most common form of dementia. There are two main types of AD: familial and sporadic. Familial AD is linked to mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), and
Paula Martinez-Feduchi, Peng Jin, Bing Yao   +2 more
doaj   +1 more source

The Effects of Treadmill Exercise on Cognitive Performance, Brain Mitochondrial Aβ-42, Cytochrome c, SOD-1, 2 and Sirt-3 Protein Expression in Mutant (N141I) Presenilin-2 Transgenic Mice of Alzheimer's Disease

, 2010
Jung‐Hoon Koo, Hyun-Sub Eum, Eun‐Bum Kang, Insu Kwon, Dong-Cheol Yeom, Gil-Young An, Yoo-Sung Oh, Young-Soo Baik, In-Ho Cho, Joon‐Yong Cho   +9 more
openalex   +2 more sources

The role of Presenilin-1 (Psen1) as a scaffold protein in the NF-ĸB mediated inflammation [PDF]

, 2019
Lavannya Sabharwal
openalex   +1 more source

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production [PDF]

, 2017
Katarzyna Marta Zoltowska, Masato Maesako, Iryna Lushnikova, Shuko Takeda, Laura J. Keller, G. G. Skibo, Bradley T. Hyman, Oksana Berezovska   +7 more
openalex   +1 more source

MOESM3 of Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention

, 2016
Cansu Agca, Diana Klakotskaia, Todd R. Schachtman, Anthony W.S. Chan, James J. Lah, Yüksel Ağca   +5 more
openalex   +1 more source

Inverse and distinct modulation of tau‐dependent neurodegeneration by presenilin 1 and amyloid‐β in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid‐β‐induced cell death [PDF]

, 2007
Julia Leschik, Alfred T. Welzel, Carina Weissmann, Anne Eckert, Roland Brandt   +4 more
openalex   +1 more source

Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function

, 2021
Jihoon Han, Heejin Park, Chinmoyee Maharana, A‐Ryeong Gwon, Jinsu Park, Seung Hyun Baek, Han‐Gyu Bae, Yoonsuk Cho, Hark Kyun Kim, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yong Eun Cho, Sun-Young Park, L. Palomera, Thiruma V. Arumugam, Mark P Mattson, Dong‐Gyu Jo   +18 more
openalex   +1 more source

Functional Domains in Presenilin 1 [PDF]

Journal of Biological Chemistry, 2004
Hanna Laudon, Helena Karlström, Paul M. Mathews, Mark R. Farmery, Samuel E. Gandy, Johan Lundkvist, Urban Lendahl, Jan Näslund   +7 more
openaire   +1 more source

Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1

, 2019
Budheswar Dehury, Ning Tang, Tom L. Blundell, Kasper P. Kepp   +3 more
openalex   +2 more sources