Results 121 to 130 of about 35,583 (221)

Different types of γ-secretes complexes and their effect on substrate processing [PDF]

, 2012
The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ- secretase complex cleaves APP at two different sites (γ- and ε-sites)
Pamrén, Annelie
core   +1 more source

APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1

Molecular Neurodegeneration, 2007
Background The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD).
Neve Rachael L, McPhie Donna L, Bodles Angela M, Chen Yuzhi, Mrak Robert E, Griffin W Sue T   +5 more
doaj   +1 more source

The very many faces of presenilins and the γ-secretase complex [PDF]

, 2013
Presenilin is a central, catalytic component of the γ-secretase complex which conducts intramembrane cleavage of various protein substrates. Although identified and mainly studied through its role in the development of amyloid plaques in Alzheimer ...
Michalina Smolarkiewicz, Przemysław Wojtaszek, Tomasz Skrzypczak   +2 more
core   +1 more source

The clinical utility of gene testing for Alzheimer’s disease

Neurology International, 2011
Alzheimer’s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a ...
Emily R. Atkins, Peter K. Panegyres
doaj   +1 more source

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Kelvin A. Yamada, Lin Xu, Steven N. Johnson, Susan Farr, William Banks   +5 more
core   +1 more source

Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors [PDF]

, 2013
BACKGROUND: Alzheimer’s disease (AD) is characterized by progressive memory loss and impaired cognitive function. Early-onset familial forms of the disease (FAD) are caused by inheritance of mutant genes encoding presenilin 1 (PS1) variants.
Karthikeyan Veeraraghavalu, Sangram S Sisodia, Se Choi, Xiaoqiong Zhang   +3 more
core   +1 more source

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. [PDF]

, 2019
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE /presenilin 1 (PS1)ΔE9 transgenic model of Aβ ...
Baufeld, Caroline, Butovsky, Oleg, Dodiya, Hemraj B, Gilbert, Jack A, Gottel, Neil, Kuntz, Thomas, Leibowitz, Jeffrey, Shaik, Shabana M, Sisodia, Sangram S, Zhang, Xiaoqiong, Zhang, Xulun   +10 more
core   +1 more source

Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders

Clinical Interventions in Aging, 2015
Yan Cai,1 Seong Soo A An,1 SangYun Kim2 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, 2Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital ...
Cai Y, An SSA, Kim SY
doaj  

Generation of human induced pluripotent stem cell line from a familial Alzheimer’s disease patient carrying missense mutations in PSEN1 and MAPT genes

Stem Cell Research
Alzheimer’s disease (AD), pathologically characterized by misfolding and accumulation of amyloid beta (Aβ) and hyperphosphorylated tau, is the leading cause of neurodegenerative dementia, accounting for 60–80 % of cases. The familial form of AD is caused
Ashaq H. Najar, Sofia E. Sepulveda, Camila Gherardelli, Fatemeh Elahian, Amber Fontenot-Roberts, Aleksandar Bajic, David H. Hunter, Claudio Soto, Paul E. Schulz, Abhisek Mukherjee   +9 more
doaj   +1 more source

Functional Domains in Presenilin 1 [PDF]

Journal of Biological Chemistry, 2004
Hanna Laudon, Helena Karlström, Paul M. Mathews, Mark R. Farmery, Samuel E. Gandy, Johan Lundkvist, Urban Lendahl, Jan Näslund   +7 more
openaire   +1 more source