Results 191 to 200 of about 35,583 (221)

The role of presenilin 1 during somite segmentation

Development, 2001
ABSTRACT The Notch signalling pathway plays essential roles during the specification of the rostral and caudal somite halves and subsequent segmentation of the paraxial mesoderm. We have re-investigated the role of presenilin 1 (Ps1; encoded by Psen1) during segmentation using newly generated alleles of the Psen1 mutation.
K, Koizumi , M, Nakajima, S, Yuasa, Y, Saga, T, Sakai, T, Kuriyama, T, Shirasawa, H, Koseki   +7 more
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Presenilin-1–associated abnormalities in regional cerebral perfusion

Neurology, 2001
To investigate the influence of the presenilin-1 gene (PS-1) mutation on regional cerebral perfusion, SPECT was evaluated in 57 individuals. The subjects were members of a large pedigree from Colombia, South America, many of whom carry a PS-1 mutation for early-onset AD.Members of this large kindred who were cognitively normal and did not carry the PS ...
K A, Johnson, F, Lopera, K, Jones, A, Becker, R, Sperling, J, Hilson, J, Londono, I, Siegert, M, Arcos, S, Moreno, L, Madrigal, J, Ossa, N, Pineda, A, Ardila, M, Roselli, M S, Albert, K S, Kosik, A, Rios   +17 more
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Metabolism and Function of Presenilin 1

1998
Neither the normal functions of presenilins nor the mechanism(s) by which familial Alzheimer’s disease (FAD)-linked mutations cause AD have been defined. Presenilin 1 (PS1) is a polytopic membrane protein that is subject to endoproteolytic processing in vivo; PS1 derivatives accumulate to saturable levels and to ~ 1:1 stoichiometry by mechanism(s) that
S. S. Sisodia, G. Thinakaran, P. C. Wong, D. R. Borchelt, M. K. Lee, A. Doan, J. Regard, H. Chen, H. Zheng, C. Eckman, H. H. Slunt, T. Ratovitsky, F. Davenport, C. Harris, L. H. T. Van der Ploeg, S. G. Younkin, N. A. Jenkins, N. G. Copeland, D. L. Price   +18 more
openaire   +1 more source

Neuronal Regulation of Presenilin-1 Processing

1998
Presenilin 1 (PS1) is ubiquitously expressed but causes pathology only in the brain. The basis of this neuropathogenic specificity is unknown. In non-neuronal cells, PS1 is localized predominantly in the endoplasmic reticulum, where it co- localizes with the resident endoplasmic reticulum protein BiP.
H. Hartmann, J. Busciglio, B. A. Yankner
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[Biochemistry of presenilin 1].

Rinsho shinkeigaku = Clinical neurology, 1998
The majority of cases of early-onset familial Alzheimer disease are caused by mutations in the recently identified presenilin 1 (PS 1) gene, located on chromosome 14. PS1, a 467 amino acid protein, is predicted to be an integral membrane protein containing seven putative transmembrane domains and a large hydrophilic loop between the sixth and seventh ...
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Role of Presenilin‐1 in Murine Neural Development

Annals of the New York Academy of Sciences, 2000
Abstract: Our previous studies showed that presenilin‐1 (PS1) is required for murine neural and skeletal development. Here we report that the reduction in the neural progenitor cells observed in the PS1−/− mouse brain is due to premature differentiation of progenitor cells, rather than to increased apoptotic cell death or decreased cell proliferation.
X, Yang, M, Handler, J, Shen
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Presenilin-1 interaction with β-catenin

Trends in Cell Biology, 1998
Last month, we published a review article by Dennis Selkoe[1xSelkoe, D. Trends Cell Biol. 1998; 8: 447–453Abstract | Full Text | Full Text PDF | PubMed | Scopus (665)See all References[1]that discussed the roles of amyloid β-protein and presenilins in Alzheimer's disease.
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Molecular consequences of presenilin-1 mutation

Nature, 2001
C. RUSSO, SCHETTINI, GENNARO, TC SAIDO, C. HULETTE, C. LIPPA, L. LANNFELT, B. GHETTI, P. GAMBETTI, TABATON, MASSIMO, JK TELLER   +9 more
openaire   +3 more sources

Presenilin-1 polymorphism and Alzheimer's disease

The Lancet, 1996
Patrick Kehoe, Julie Williams, Simon Lovestone, Gordon Wilcock, MichaelJ. Owen, Constantin Bouras, Panteleimon Giannakopoulos, Junichi Schioi, Nikolaos Tezapsidis, NikolaosK. Robakis, Susumu Higuchi, Taro Muramatsu, Sachio Matsushita, Hiroyuki Arai, Hidetada Sasaki, WilliamK. Scott, JohnH. Growdon, AllenD. Roses, JonathanL. Haines, MargaretA. Pericak-Vance   +19 more
  +4 more sources

The role of presenilin cofactors in the γ-secretase complex

Nature, 2003
Nobumasa Takasugi, Taisuke Tomita, Gopal Thinakaran   +2 more
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