Results 191 to 200 of about 24,368 (229)

Presenilin-1 is located in rat mitochondria

Biochemical and Biophysical Research Communications, 2002
Presenilins are mutated in most cases of autosomal dominant inherited forms of early onset Alzheimer's disease and such mutations are known to sensitize cells to apoptotic stimuli in vitro. Previous studies show that presenilins are primarily located in the endoplasmatic reticulum and cell membranes.
Maria, Ankarcrona, Kjell, Hultenby
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Presenilin-1 expression in Pick's disease

Acta Neuropathologica, 1999
Recent studies have reported that neuronal populations expressing low levels of presenilin-1 (PS-1) display increased vulnerability in late-onset sporadic Alzheimer's disease (AD). To examine whether this phenomenon also occurs in other neurodegenerative diseases, we performed a quantitative immunocytochemical study of PS-1 distribution in the cerebral
Giannakopoulos P, Kövari E, Buée L, Shioi J, Hof PR, Robakis NK, Bouras C   +6 more
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Presenilin-1 mutations in Alzheimer's disease

Nature, 2000
Mutations in the gene encoding the protein presenilin-1 are the most common cause of familial Alzheimer's disease1 and they often produce a different disease course from sporadic Alzheimer's and another familial form associated with mutations in the gene encoding β-amyloid precursor protein2.
RUSSO, Claudio, SCHETTINI G., SAIDO T. C., HULETTE C., LIPPA C., LANNFELT L., GHETTI B., GAMBETTI P., TABATON M., TELLER J. K.   +9 more
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Amyloidogenic and anti-amyloidogenic properties of presenilin 1

2021
Presenilin 1 (PS1) is an intramembrane protease, the active subunit of the γ-secretase complex. Its well-studied function is the amyloidogenic cleavage of the C-terminal fragment of the amyloid precursor protein, also known as C99, to produce the Abeta peptide.
Victor, Bustos, Maria V, Pulina, Jose, Ledo   +2 more
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Presenilin-1 in late-onset depressive disorder

Psychiatry Research, 2000
Late-onset depressive disorder (LOD) is thought to be associated with dementia. Allele 1 in the presenilin-1 (PS-1) gene is a risk factor for Alzheimer's disease. An association study on this polymorphism was performed in depressive patients and control subjects. The patients were subdivided into those with early onset and late onset, using 50 years as
K, Ohara, Y, Suzuki, D, Ohta, K, Ohara
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The role of presenilin 1 during somite segmentation

Development, 2001
ABSTRACT The Notch signalling pathway plays essential roles during the specification of the rostral and caudal somite halves and subsequent segmentation of the paraxial mesoderm. We have re-investigated the role of presenilin 1 (Ps1; encoded by Psen1) during segmentation using newly generated alleles of the Psen1 mutation.
K, Koizumi , M, Nakajima, S, Yuasa, Y, Saga, T, Sakai, T, Kuriyama, T, Shirasawa, H, Koseki   +7 more
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Presenilin-1 is indirectly implicated in Notch1 cleavage

NeuroReport, 2003
It has been previously demonstrated that the Notch1 signalling pathway is impaired in presenilin-1 null cells. This observation suggests a role for presenilin-1 in the Notch1 developmental pathway, possibly through physical interaction. Here, we show that presenilin-1 and Notch1 do not interact directly with each other but are associated in the cell ...
Chantal, Godin, Annie, Auclair, Mélissa, Ferland, Sébastien S, Hébert, Madeleine, Carreau, Georges, Lévesque   +5 more
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Metabolism and Function of Presenilin 1

1998
Neither the normal functions of presenilins nor the mechanism(s) by which familial Alzheimer’s disease (FAD)-linked mutations cause AD have been defined. Presenilin 1 (PS1) is a polytopic membrane protein that is subject to endoproteolytic processing in vivo; PS1 derivatives accumulate to saturable levels and to ~ 1:1 stoichiometry by mechanism(s) that
S. S. Sisodia, G. Thinakaran, P. C. Wong, D. R. Borchelt, M. K. Lee, A. Doan, J. Regard, H. Chen, H. Zheng, C. Eckman, H. H. Slunt, T. Ratovitsky, F. Davenport, C. Harris, L. H. T. Van der Ploeg, S. G. Younkin, N. A. Jenkins, N. G. Copeland, D. L. Price   +18 more
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Implications of presenilin 1 mutations in Alzheimer’s disease

Mechanisms of Ageing and Development, 1999
Mutations in presenilin 1 (PS1) and presenilin 2 (PS2) are the most common genetic factors underlying the development of early-onset familial Alzheimer's disease (FAD). To investigate the pathogenic mechanism of PS1 mutations linked to FAD, we established inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated
H, Komano, S, Sudoh, Y, Kawamura, R, Wang, K, Yanagisawa   +4 more
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The regulation of presenilin‐1 by nerve growth factor

Journal of Neurochemistry, 2001
Presenilin‐1 (PS1) protein concentration is linked to neuronal development and to the pathogenesis of Alzheimer's disease, yet little is known about the biological factors and mechanisms that control cellular levels of PS1 protein. As PS1 levels are highest in the developing brain, we tested whether neurotrophin‐induced differentiation influences PS1 ...
S E, Counts, J J, Lah, A I, Levey
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