Results 201 to 210 of about 24,368 (229)

Cloning of the cDNA encoding rat Presenilin-1

Gene, 1997
We isolated rat presenilin-1 (PS-1; also called S182 previously) cDNA from total brain RNA by using a reverse transcription-polymerase chain reaction (RT-PCR) technique with primers homologous to the conserved sequences of human and mouse PS-1. Rat PS-1 cDNA encoded 468 amino acids (aa) and the deduced aa sequence was highly homologous to those of the ...
T, Taniguchi, T, Hashimoto, R, Taniguchi, K, Shimada, T, Kawamata, M, Yasuda, M, Nakai, A, Terashima, T, Koizumi, K, Maeda, C, Tanaka   +10 more
openaire   +2 more sources

Characterization and expression of presenilin 1 in mouse brain

NeuroReport, 1996
The expression pattern of presenilin 1 (PS-1) in adult mouse brain was investigated using antibodies to specific peptides of PS-1. One antibody, Alz14A, specifically detected a 53 kDa protein in retinoic acid-treated P19 cells and mouse brain protein extracts consistent with the predicted PS-1 molecular weight.
D P, Huynh, V V, Ho, S M, Pulst
openaire   +2 more sources

Role of Presenilin‐1 in Murine Neural Development

Annals of the New York Academy of Sciences, 2000
Abstract: Our previous studies showed that presenilin‐1 (PS1) is required for murine neural and skeletal development. Here we report that the reduction in the neural progenitor cells observed in the PS1−/− mouse brain is due to premature differentiation of progenitor cells, rather than to increased apoptotic cell death or decreased cell proliferation.
X, Yang, M, Handler, J, Shen
openaire   +2 more sources

[Biochemistry of presenilin 1].

Rinsho shinkeigaku = Clinical neurology, 1998
The majority of cases of early-onset familial Alzheimer disease are caused by mutations in the recently identified presenilin 1 (PS 1) gene, located on chromosome 14. PS1, a 467 amino acid protein, is predicted to be an integral membrane protein containing seven putative transmembrane domains and a large hydrophilic loop between the sixth and seventh ...
openaire   +1 more source

Inhibition of AMPA responses by mutated presenilin 1

Journal of Neuroscience Research, 1999
The inheritance of Alzheimer's disease in some families, as well as ablation/rescue genetics in mice, suggest that point mutations in the presenilin-1 (PS1) gene can cause disease through an unknown gain-of-function. While mutations associated with familial Alzheimer's can alter apoptotic rates and beta-amyloid precursor processing, it is possible that
A M, Moerman, S W, Barger
openaire   +2 more sources

Localization of presenilin-1 mRNA in rat brain

NeuroReport, 1996
We examined the regional and cellular distribution of presenilin-1 gene expression in the rat brain by in situ hybridization. Microscopic analysis demonstrated that presenilin-1 mRNA is predominantly expressed in areas such as the occipital cortex, the pyramidal layer of the hippocampus, thalamic nuclei and the cerebellar granular layer. The expression
D, Quarteronet, L, Pradier, C, Czech, L, Delalonde, M C, Burgevin, A, Doble, F, Petitet   +6 more
openaire   +2 more sources

Molecular consequences of presenilin-1 mutation

Nature, 2001
C. RUSSO, SCHETTINI, GENNARO, TC SAIDO, C. HULETTE, C. LIPPA, L. LANNFELT, B. GHETTI, P. GAMBETTI, TABATON, MASSIMO, JK TELLER   +9 more
openaire   +2 more sources

Cellular Expression and Proteolytic Processing of Presenilin Proteins Is Developmentally Regulated During Neuronal Differentiation

Journal of Neurochemistry, 1997
Anja Capell, Rainer Saffrich, Jochen Walter   +2 more
exaly  

Identification and characterization of presenilin I-467, I-463 and I-374

FEBS Letters, 1996
Naruhiko Sahara, Takefumi Kondo, Masayasu Okochi   +2 more
exaly  

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

EMBO Journal, 2002
Philippe Marambaud, Junichi Shioi, Lia Baki   +2 more
exaly