Results 181 to 190 of about 35,583 (221)

Presenilin-1 in Neuroblastoma Cells

Toxicology in Vitro, 1998
Presenilin-1 expression was investigated in Neuro-2a cells using the alphaPS1Loop antibody. The bulk of the immunoreactivity was found as the approximately 18kDa C-terminal fragment. Hydrogen peroxide treatment of the Neuro-2a cells for 24 hours resulted in a concentration-dependent cytotoxicity with a critical concentration of hydrogen peroxide of ...
C, Lindblad, H, Hedin, G, Andersson, C J, Fowler   +3 more
openaire   +2 more sources

Presenilin-1 mutations in Alzheimer's disease

Nature, 2000
Mutations in the gene encoding the protein presenilin-1 are the most common cause of familial Alzheimer's disease1 and they often produce a different disease course from sporadic Alzheimer's and another familial form associated with mutations in the gene encoding β-amyloid precursor protein2.
M Tabaton, Bradley T Hyman
exaly   +5 more sources

Regulation of Apoptosis by Presenilin 1

Neurobiology of Aging, 1998
Familial Alzheimer's disease is transmitted as an autosomal dominant disorder and, in 5-10% of the cases, is caused by mutations in the coding regions of two homologous genes, Presenilin 1 and 2 (PS1 and PS2). Previously, we have shown that PS2, a homolog of PS1.
B, Wolozin, P, Alexander, J, Palacino
openaire   +2 more sources

Presenilin-1 expression in Pick's disease

Acta Neuropathologica, 1999
Recent studies have reported that neuronal populations expressing low levels of presenilin-1 (PS-1) display increased vulnerability in late-onset sporadic Alzheimer's disease (AD). To examine whether this phenomenon also occurs in other neurodegenerative diseases, we performed a quantitative immunocytochemical study of PS-1 distribution in the cerebral
P, Giannakopoulos, E, Kövari, L, Buée, J, Shioi, P R, Hof, N K, Robakis, C, Bouras   +6 more
openaire   +2 more sources

Presenilin-1 in late-onset depressive disorder

Psychiatry Research, 2000
Late-onset depressive disorder (LOD) is thought to be associated with dementia. Allele 1 in the presenilin-1 (PS-1) gene is a risk factor for Alzheimer's disease. An association study on this polymorphism was performed in depressive patients and control subjects. The patients were subdivided into those with early onset and late onset, using 50 years as
K, Ohara, Y, Suzuki, D, Ohta, K, Ohara
openaire   +2 more sources

Presenilin 1: more than just γ-secretase

Biochemical Society Transactions, 2005
Presenilin 1 plays a central catalytic role in the γ-secretase processing of amyloid precursor protein, Notch and many other substrates. However, this core component clearly mediates independently several other physiological roles in the cell/neuron. Besides its involvement in β-catenin degradation, we discuss here the recent implication of presenilin ...
T, Raemaekers, C, Esselens, W, Annaert
openaire   +2 more sources

Presenilin-1 regulates neuronal differentiation during neurogenesis

Development, 2000
ABSTRACT Mutations in Presenilin-1 (PSP) are a major cause of familial Alzheimer’s disease. Our previous studies showed that PS1 is required for murine neural development. Here we report that lack of PS1 leads to premature differentiation of neural progenitor cells, indicating a role for PS1 in a cell fate decision between postmitotic ...
M, Handler, X, Yang, J, Shen
openaire   +2 more sources

Presenilin-1 is located in rat mitochondria

Biochemical and Biophysical Research Communications, 2002
Presenilins are mutated in most cases of autosomal dominant inherited forms of early onset Alzheimer's disease and such mutations are known to sensitize cells to apoptotic stimuli in vitro. Previous studies show that presenilins are primarily located in the endoplasmatic reticulum and cell membranes.
Maria, Ankarcrona, Kjell, Hultenby
openaire   +2 more sources

Amyloidogenic and anti-amyloidogenic properties of presenilin 1

2021
Presenilin 1 (PS1) is an intramembrane protease, the active subunit of the γ-secretase complex. Its well-studied function is the amyloidogenic cleavage of the C-terminal fragment of the amyloid precursor protein, also known as C99, to produce the Abeta peptide.
Victor, Bustos, Maria V, Pulina, Jose, Ledo   +2 more
openaire   +2 more sources

Implications of presenilin 1 mutations in Alzheimer’s disease

Mechanisms of Ageing and Development, 1999
Mutations in presenilin 1 (PS1) and presenilin 2 (PS2) are the most common genetic factors underlying the development of early-onset familial Alzheimer's disease (FAD). To investigate the pathogenic mechanism of PS1 mutations linked to FAD, we established inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated
H, Komano, S, Sudoh, Y, Kawamura, R, Wang, K, Yanagisawa   +4 more
openaire   +2 more sources