Results 161 to 170 of about 24,368 (229)

Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation [PDF]

Dehua Chui, Hiroshi Tanahashi, Kazuharu Ozawa, Sachiya Ikeda, Frédéric Checler, Otoya Ueda, Hiroshi Suzuki, Wataru Araki, Haruhisa Inoue, Keiro Shirotani, Keikichi Takahashi, Ferenc Gallyas, Takeshi Tabira   +12 more
openalex   +1 more source

Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss. [PDF]

Alzheimers Dement
Yeapuri P, Machhi J, Foster EG, Kadry R, Bhattarai S, Lu Y, Sil S, Sapkota R, Srivastava S, Kumar M, Ikezu T, Poluektova LY, Gendelman HE, Mosley RL.   +13 more
europepmc   +1 more source

Mutation of Conserved Aspartates Affects Maturation of Both Aspartate Mutant and Endogenous Presenilin 1 and Presenilin 2 Complexes

, 2000
Gang Yu, Fusheng Chen, Masaki Nishimura, Harald Steiner, Anurag Tandon, Toshitaka Kawarai, Shigeki Arawaka, Agnes Supala, You‐Qiang Song, Ekaterina Rogaeva, Erin Holmes, Dong Mei Zhang, Paul Milman, Paul E. Fraser, Christian Haass, Peter St George‐Hyslop   +15 more
openalex   +1 more source

Kv1.1 channel dysfunction in parvalbumin-positive interneurons contributes to anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout mice. [PDF]

Cell Biosci
Yang G, Zhao Y, Zhao C, Yan J, Xia Y, Li K, Wu Y, Wang X, Zhang M, Chen Y, Xu Y.   +10 more
europepmc   +1 more source

A familial Alzheimer's disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration. [PDF]

PLoS One
Parvand M, Liang JJH, Bozorgmehr T, Born D, Luna Cortes A, Rankin CH.   +5 more
europepmc   +1 more source

Expression of Concern: Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce β-amyloid in Alzheimer's disease. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

A Novel p.Leu(381)Phe Mutation in Presenilin 1 is Associated with Very Early Onset and Unusually Fast Progressing Dementia as well as Lysosomal Inclusions Typically Seen in Kufs Disease

, 2014
Natalia Dolzhanskaya, Michael Gonzalez, Fiorella Sperziani, Shannon Stefl, Jeffrey M. Messing, G. Y. Wen, Emil Alexov, Stephan Züchner, Milen Velinov   +8 more
openalex   +2 more sources

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

, 1996
David G. Cook, Jaemyoung Sung, Todd E. Golde, Kevin M. Felsenstein, Bogusław S. Wójczyk, Rudolph E. Tanzi, J Q Trojanowski, V M Lee, Robert W. Doms   +8 more
openalex   +1 more source

Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes. [PDF]

J Neuropathol Exp Neurol
Sepulveda-Falla D, Villegas Lanau CA, White Iii C, Serrano GE, Acosta-Uribe J, Mejía-Cupajita B, Villalba-Moreno ND, Lu P, Glatzel M, Kofler JK, Ghetti B, Frosch MP, Restrepo FL, Kosik KS, Beach TG.   +14 more
europepmc   +1 more source

An Upstream Element Containing an ETS Binding Site Is Crucial for Transcription of the Human Presenilin-1 Gene

, 1999
Martine Pastorcic, Hriday K. Das
openalex   +1 more source