Results 151 to 160 of about 35,583 (221)

Case Report: Acute Psychiatric Behavioral Disturbance in a Patient with Presenilin 1 Gene Mutation Associated with Familial Alzheimer's Disease. [PDF]

Neurol Ther
Xia Y, Liu X, Cui W, Zhi Q, Sun Y.
europepmc   +1 more source

Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout mice. [PDF]

Front Aging Neurosci, 2022
Peng W, Xie Y, Liao C, Bai Y, Wang H, Li C.   +5 more
europepmc   +1 more source

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex Formation. [PDF]

Biomolecules
Devkota S, Maesako M, Wolfe MS.
europepmc   +1 more source

Rare A360T Mutation Alters GSK3β(Ser9) Binding in the Cytosolic Loop of Presenilin 1, Influencing β-Catenin Nuclear Localization and Pro-Death Gene Expression in Alzheimer's Disease Case. [PDF]

Int J Mol Sci, 2023
Wężyk M, Berdyński M, Figarski A, Skrzypczak M, Ginalski K, Zboch M, Winkel I, Żekanowski C.   +7 more
europepmc   +1 more source

Mitochondrial dysfunction and Ca²⁺ dysregulation in human iPSC-derived neurons carrying presenilin-1 mutation arise under stress via an MCU-1-independent mechanism. [PDF]

Sci Rep
Wilson C, Galeano P, Remedi MM, Novack GV, Campanelli L, Gastaldi L, Miglietta E, Rossi AH, Olivar N, Brusco LI, Castaño EM, Cáceres A, Morelli L.   +12 more
europepmc   +1 more source

TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail. [PDF]

J Biol Chem
Moon OR, Newman AC, Alanazi AS, Wehenkel SC, Gawel-Bęben K, Ivetic A, Price DA, Knäuper V, Ager A.   +8 more
europepmc   +1 more source

Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss. [PDF]

Alzheimers Dement
Yeapuri P, Machhi J, Foster EG, Kadry R, Bhattarai S, Lu Y, Sil S, Sapkota R, Srivastava S, Kumar M, Ikezu T, Poluektova LY, Gendelman HE, Mosley RL.   +13 more
europepmc   +1 more source

Kv1.1 channel dysfunction in parvalbumin-positive interneurons contributes to anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout mice. [PDF]

Cell Biosci
Yang G, Zhao Y, Zhao C, Yan J, Xia Y, Li K, Wu Y, Wang X, Zhang M, Chen Y, Xu Y.   +10 more
europepmc   +1 more source

γ-Secretase; presenilin 1 (PSEN1; PS1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

A familial Alzheimer's disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration. [PDF]

PLoS One
Parvand M, Liang JJH, Bozorgmehr T, Born D, Luna Cortes A, Rankin CH.   +5 more
europepmc   +1 more source