Results 91 to 100 of about 2,788,343 (358)

Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy

Journal of Clinical Oncology, 2022
J. García-Aguilar, S. Patil, M. Gollub, Jin K. Kim, J. Yuval, Hannah M Thompson, F. Verheij, D. Omer, Meghan E. Lee, R. Dunne, J. Marcet, P. Cataldo, B. Polite, Daniel O. Herzig, D. Liska, S. Oommen, C. Friel, C. Ternent, A. Coveler, S. Hunt, A. Gregory, M. Varma, B. Bello, J. Carmichael, J. Krauss, A. Gleisner, P. Paty, M. Weiser, G. Nash, E. Pappou, José G. Guillem, L. Temple, I. Wei, M. Widmar, Sabrina T. Lin, N. Segal, A. Cercek, R. Yaeger, J. Smith, K. Goodman, A. Wu, L. Saltz   +41 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mechanistic study of the effect of a high-salt diet on the intestinal barrier

Scientific Reports
Despite the established link between chronic high salt diet (HSD) and an increase in gut inflammation, the effect of HSD on the integrity of the intestinal barrier remains understudied.
Li Chen, Junrui Tang, Yanglin Xia, Jie Wang, Li-na Xia   +4 more
doaj   +1 more source

Book Review: Archeology in the Eastern Planning Region, Texas: A Planning Document [PDF]

, 1996
With the passage of the National Historic Preservation Act in 1966 and ensuing regulatory guidelines, a mandate for the development of The State Historic Preservation Plan was clearly established. During the late 1960s and the 1970s, because of limited
Brooks, Robert L.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Critical Role of Autophagy in the Pathogenesis of Diabetic Osteoporosis: Mechanisms and Therapeutic Measures

Drug Design, Development and Therapy
Kehao Hou,* Weipeng Shi,* Kuishuai Xu, Tianrui Wang, Yingze Zhang Knee Preservation Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China*These authors contributed equally to
Hou K, Shi W, Xu K, Wang T, Zhang Y
doaj  

The woody vegetation communities of the Hluhluwe-Corridor- Umfolozi Game Reserve Complex

Bothalia: African Biodiversity & Conservation, 1983
Land units for the 900 km- Hluhluwe-Corridor-Umfolozi Game Reserve Complex in north eastern Natal were identified on aerial photographs. The physiognomy, dominants and description of the woody vegetation for each unit were identified during ground ...
A. Whateley, R. N. Porter
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Issues in digital preservation: towards a new research agenda [PDF]

, 2010
Digital Preservation has evolved into a specialized, interdisciplinary research discipline of its own, seeing significant increases in terms of research capacity, results, but also challenges. However, with this specialization and subsequent formation of
Casarosa, V., Chanod, J., Dobreva, M., Rauber, A., Ross, S.   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source