Results 81 to 90 of about 1,238,092 (248)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

International Internet Preservation Consortium Quarterly highlight report: November - December 2010

, 2011
This report summarizes the activities of the International Internet Preservation Consortium Preservation Working Group from the fourth quarter of ...
International Internet Preservation Consortium. Preservation Working Group
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Archived Webinar: Media Preservation

, 2012
Archived webinar.Content is available at the link in the URI fieldMade available in DSpace on 2013-05-08T20:58:48Z (GMT). No. of bitstreams: 1 license.txt: 4923 bytes, checksum: 3568ab34bde24044ec8ea05b1192aa03 (MD5) Previous issue date:Institute of ...
Illinois Collections Preservation Network
core  

Digital curation bibliography: preservation and stewardship of scholarly works [PDF]

, 2012
In a rapidly changing technological environment, the difficult task of ensuring long-term access to digital information is increasingly important. This publication presents over 650 English-language articles, books, and technical reports that are useful
Bailey, Charles, Bailey, Charles W., Charles W. Bailey, Bailey, Charles W., Jr.   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

IIPC Preservation Working Group Report to IIPC Steering Committee

, 2007
This report summarizes the formation of the Preservation Workgroup and its work conducted between June to December ...
International Internet Preservation Consortium. Preservation Working Group
core  

New direction: identification of immunoinflammatory subtypes and potential therapeutic targets for cholangiocarcinoma

Discover Oncology
Background Cholangiocarcinoma (CHOL) is a rare cancer with low survival rates. Despite advances in precision medicine targeting molecular subtypes, the immune subtypes of CHOL remain poorly understood. This study aimed to identify immune subtypes of CHOL
Zhixuan Chen, Honghu Song, Junrui Tang, Jiao Liu, Lina Xia   +4 more
doaj   +1 more source

Intestinal Absorption and Anti-Inflammatory Effects of a Low-Molecular-Weight α-Glucan from Flammulina filiformis

Foods
The health benefits of Flammulina filiformis polysaccharides (FFPs) are often attributed to high-molecular-weight (HMW) fractions, which act via the gut microbiota.
Yue Li, Mengmeng He, Ziyi Xu, Jianhui Liu, Haoru Zhao, Qiuhui Hu, Fei Pei, Wenjian Yang, Anxiang Su   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source