Results 121 to 130 of about 2,788,343 (358)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Data Preservation at LEP

, 2009
The four LEP experiments ALEPH, DELPHI, L3 and OPAL successfully recorded e+e- collision data during the years 1989 to 2000. As part of the ordinary evolution in High Energy Physics, these experiments can not be repeated and their data is therefore ...
Gokieli, Ryszard, Holzner, André G., Igo-Kemenes, Peter, Maggi, Marcello, Malgeri, Luca, Mele, Salvatore, Pape, Luc, Plane, David, Schröder, Matthias, Schwickerath, Ulrich, Tenchini, Roberto, Timmermans, Jan   +11 more
core  

Develop Guidelines for Pavement Preservation Treatments and for Building a Pavement Preservation Program Platform for Alaska [PDF]

, 2012
INE/AUTC 12 ...
Cheng, DingXin, Hicks, Gary, Liu, Jenny, Mullins, Tony, Zubeck, Hannele   +4 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

New direction: identification of immunoinflammatory subtypes and potential therapeutic targets for cholangiocarcinoma

Discover Oncology
Background Cholangiocarcinoma (CHOL) is a rare cancer with low survival rates. Despite advances in precision medicine targeting molecular subtypes, the immune subtypes of CHOL remain poorly understood. This study aimed to identify immune subtypes of CHOL
Zhixuan Chen, Honghu Song, Junrui Tang, Jiao Liu, Lina Xia   +4 more
doaj   +1 more source

Bark and wood tissues of American elm exhibit distinct responses to Dutch elm disease

Scientific Reports, 2017
Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O.
S. M. Sherif, L. A. Erland, M. R. Shukla, P. K Saxena   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Greening Historic DC: Challenges and Opportunities to Incorporate Historic Preservation into the District\u27s Drive for Sustainable Development [PDF]

, 2009
This paper focuses primarily on the District of Columbia, a city with a robust past and a bold agenda for a sustainable future. However, it may not be obvious why historic preservation - a movement typically concerned with aesthetics - can play an ...
Stein, Andrew
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Salt sensitivity potentiates high-salt diet-induced intestinal barrier disruption and gut microbiome dysbiosis in rats

Frontiers in Microbiology
IntroductionThe high-salt diet is a prevalent eating habit associated with health risks. This study investigated the impact of high salt on intestinal barrier disruption and gut microbiome dysbiosis using Wistar and Dahl salt-sensitive rat models ...
Baihan Zeng, Xile Peng, Pengyang Xiao, Kaidi Nie, Guilong Zhang, Lina Xia   +5 more
doaj   +1 more source