Results 131 to 140 of about 1,238,092 (248)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Vagus nerve-fibre preservation during resection of vagal paraganglioma: a case series with patient-reported outcomes. [PDF]

J Surg Case Rep
Leadon M, Howard T, Ovenell A, Clarke PM, Bernstein JM.   +4 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Piecing Together the Jigsaw: the framework for a national preservation strategy for libraries and archives. Proceedings of the National Preservation Office Conference 18-20 September 1995, York

, 1995
The National Preservation Office (NPO) conferences have gained a reputation for their wide-ranging topics. their sincere attempt to address issues which can be at times difficult to 'pin down', and their down-to-earth approach. Such was the case with the
National Preservation Office
core  

Preservation in Perspective

The ‘Preservation in Perspective’ conference, held in 2021 to mark the 10th anniversary of the Coordination Office for the Preservation of Written Cultural Heritage (KEK), provided an opportunity to discuss the present and future of original preservation.

core   +1 more source

Selective under-representation of transcripts encoding membrane-integrated architectures following neural tissue vitrification. [PDF]

Biochem Biophys Rep
Wilczok D, Long Q, Huang Z, Kangas J, Liu Y, Wang M, Kappes F.   +6 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Knowledge, attitudes, and practices of gynecologic oncology nurses toward patient decision aids for fertility preservation: a cross-sectional study in Zhengzhou, China. [PDF]

Front Public Health
Han X, Li X, Li M, Tian T, Shi K, Shi Y, Zhang F.   +6 more
europepmc   +1 more source