Results 31 to 40 of about 10,653,560 (307)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Beyond materiality: mud as a living material in heritage preservation

open access: yesFrontiers in Sustainable Cities
This paper investigates the multifaceted role of mud in heritage preservation, focusing on the Bayt Isa restoration project in old Irqah within Wadi Hanifa, a site rich in historical significance in the Kingdom of Saudi Arabia.
Roula El-Khoury   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Preservation of alveolar ridge using graft material after tooth extraction: A clinical trial

open access: yesJournal of Pharmacy and Bioallied Sciences, 2021
Background: The alveolar process is a tooth-dependent structure, and hence, removal of teeth results in the alteration of alveolar process. To alter bone remodeling after dental extraction, various techniques have been put forward for ridge preservation.
Kunal Kumar   +5 more
doaj   +1 more source

Damage preserving transformation for materials with microstructure

open access: yesEuropean Journal of Mechanics - A/Solids, 2023
The failure of heterogeneous materials with microstructures is a complex process of damage nucleation, growth and localisation. This process spans multiple length scales and is challenging to simulate numerically due to its high computational cost. One option is to use domain decomposed multi-scale methods with dynamical refinement.
Philip P. Müller   +2 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Ridge Preservation and Augmentation Using a Carbonated Apatite Bone Graft Substitute: A Case Series

open access: yesDentistry Journal
The newly developed mineral carbonated apatite has recently been proposed as a bone graft material for bone regenerative treatment in implant therapy.
Yoichi Taniguchi   +5 more
doaj   +1 more source

VREDEN RUSSIAN RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPEDICS

open access: yesTravmatologiâ i Ortopediâ Rossii, 2017
Currently, the use of bone allografts for reconstructive orthopedic surgery in clinical practice around the world is becoming a common procedure. Bone allografts are the first substitute material to the autologous bone and the best alternative to any ...
K. A. Vorobyоv   +3 more
doaj   +1 more source

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