Results 51 to 60 of about 223,556 (265)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

From Memory to Reality: Preserving and Transmitting Collective Memory in Urban Historic Neighborhoods

SAGE Open
Historic neighborhoods are crucial repositories of a city’s cultural heritage. However, during urban renewal and development, the emphasis often falls on physical preservation and renovation, leading to the neglect of the “collective memory” inherent in ...
Yuting Dai, Jingru Zhang, Jie Zhang, Wan Ahmad Jaafar Wan Yahaya   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sustaining urban memory through oyster shell Architecture: constructing an evaluation framework for vernacular heritage Planning in Guangzhou

Journal of Asian Architecture and Building Engineering
This study tackles the preservation of oyster shell walls, a unique Lingnan vernacular architectural heritage, amid Guangzhou’s urbanization. Facing commercial development, material degradation, and cultural identity loss, a systematic evaluation ...
Ruyi Han, Sijia Cai, Xuefei Li, Shawei Zhang, Ge Wang   +4 more
doaj   +1 more source

Preparation of Composite Preservation Paper Containing Antagonistic Fungi and Its Application on Apple Preservation

Shipin gongye ke-ji
In order to study the properties of composite preservation paper containing antagonistic fungi and the effect of the composite preservation paper on the physiological quality and preservation quality of Gala apples at room temperature, and at the same ...
Yixuan LIU, Hong YUE, Xinyu SI, Menghan ZHOU, Cunkun CHEN, Honglian GUO   +5 more
doaj   +1 more source

Challenges in preservation and archiving digital materials

Information Services and Use, 2020
At its most basic, digital preservation comprises a series of risks, and strategies to mitigate them. And no matter the scale or type of collections, whether born-digital, digitized, or both, the same challenges and risks apply and similar strategies can be employed.
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Alveolar Ridge Preservation Using a Novel Species-Specific Collagen-Enriched Deproteinized Bovine Bone Mineral: Histological Evaluation of a Prospective Case Series

Bioengineering
In recent years, the significance of maintaining the alveolar ridge following tooth extractions has markedly increased. Alveolar ridge preservation (ARP) is a commonly utilized technique and a variety of bone substitute materials and biologics are ...
Andreas van Orten, Werner Goetz, Hakan Bilhan   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Socket preservation

Padjadjaran Journal of Dentistry, 2015
Alveolar ridge will commonly decrease in volume and change morphologically, as a result of a tooth loss. These changes are usually clinically significant and can make placement of a conventional protesa  or an implant more difficult.
Caecilia Susetya Wahyu Nurhaeini, Ira Komara   +1 more
doaj   +1 more source