Results 61 to 70 of about 223,556 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

High-barrier cellulose-based packaging material for enhanced food preservation with visual freshness monitoring

Journal of Bioresources and Bioproducts
In recent years, there has been a growing interest in the development of cellulose or nanocellulose (CNF) materials in food packaging industry due to their green and processable nature, while the inherent hydrophilicity of cellulose presents significant ...
Ruotong Yao, Chao Wang, Yunli Xu, Min Wu
doaj   +1 more source

Patrimoniul arhitectural industrial romanesc – trecut şi prezent [PDF]

Urbanism. Arhitectura. Constructii, 2012
The development of industrial activities on the Romanian territory is experiencing a considerable seniority, generating as a result an industrial heritage that stands out through its versatility (history, technology, architecture and esthetic).
Daniela Stoian, George-Laurenţiu Merciu, Florentina-Cristina Merciu   +2 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of the Effectiveness of the Socket Preservation Technique Using Allogeneic and Xenogeneic Materials—A Preliminary Study

Journal of Functional Biomaterials
Background: The socket preservation technique involves filling the bone defect created after tooth extraction with a bone substitute material. This helps to reduce bone resorption of the post-extraction alveolar ridge.
Piotr Wróbel, Adam Piecuch, Michał Bąk, Paweł Krynicki, Jakub Adamczyk, Piotr Mojżesz, Agnieszka Kiełboń, Sylwia Wójcik, Martin Starosta, Won-Pyo Lee, Tadeusz Morawiec   +10 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effects of four packaging materials on preservation of passion flower （Passiflora caerulea L.） fruit

Shipin yu jixie
Objective: The preservation effects of four packaging materials on passion fruit were studied. Methods: The fruit of passion flower cv. Huangjin （maturity: eight） was used as the research material, and passion flower fruit was treated via polyvinyl ...
LIN Yuzhao, CHEN Leiyi, CHEN Hongbin, ZHENG Jinshui, JIANG Xuanjing, YANG Jingmei   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The preservation and utilization of visual materials in NHK.

Journal of Information Processing and Management, 1989
NHK(日本放送協会)が保存する映像資料(ビデオテープとフィルム)は32万巻にのぼる。本稿では, 1953年(昭和28)のテレビ放送開始以来蓄積されてきた映像資料が, 良好な画質を保ちつつ, いかに利用されやすく整理・保管されているかを紹介する。また, このぼう大な資料を迅速に検索するために構築されたデータベースの概要もあわせて紹介する。
openaire   +2 more sources