Results 61 to 70 of about 1,061,857 (308)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Code of Best Practices in Fair Use for the Visual Arts [PDF]

, 2015
This Code of Best Practices provides visual-arts professionals with a set of principles addressing best practices in the fair use of copyrighted materials.

core  

Dark Matter directional detection: comparison of the track direction determination

, 2016
Several directional techniques have been proposed for a directional detection of Dark matter, among others anisotropic crystal detectors, nuclear emulsion plates, and low-pressure gaseous TPCs.
Couturier, C., Naraghi, F., Santos, D., Sauzet, N., Zopounidis, J. P.   +4 more
core   +3 more sources

Improvement of lung preservation - From experiment to clinical practice [PDF]

, 2002
Background. Reperfusion injury represents a severe early complication following lung transplantation. Among the pathogenetic factors, the high potassium content of Euro-Collins(R) solution is discussed.
Bittmann, I., Fürst, H., Hatz, Rudolf A., Kellner, B., Müller, Ch., Reichart, B., Schelling, G., Schildberg, Friedrich Wilhelm   +7 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Antibacterial and antifungal activities of Platycladus orientalis leaf extract-mediated Fe2O3 and Ce-doped Fe2O3 nanoparticles

Discover Applied Sciences
Green synthesis of nanomaterials harnesses naturally occurring materials, including plant extracts, to offer environmentally friendly alternatives to conventional biomedicine, agriculture, and other field applications. This study explores the green route
Mercy C. Ogwuegbu, Olalekan C. Olatunde, Trust M. Pfukwa, Doctor M. N. Mthiyane, Olaniyi A. Fawole, Damian C. Onwudiwe   +5 more
doaj   +1 more source

Designing the past: the National Trust as a social-material agency [PDF]

, 2009
The National Trust was founded in 1895 for ‘the preservation of places of historic interest or natural beauty’. While the distinction between the cultural and the natural seemed obvious at that time and members and visitors were not even implicated ...
Fox, Dorothy, Johnston, Nicky, Wallace, Stephen   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Three case studies in virtual preservation. Applying virtual reality to Cultural Heritage

Agathón, 2019
The paper documents three case studies researching the techniques of Virtual Preservation upon various Cultural Heritage sites in order to preserve material aspects that, in the near future, can be irreparably damaged by the impact of climate change ...
Kai Reaver
doaj   +1 more source