Results 71 to 80 of about 1,061,857 (308)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Heritage Value Assessment and Landscape Preservation of Traditional Chinese Villages Based on the Daily Lives of Local Residents: A Study of Tangfang Village in China and the UNESCO HUL Approach

Land
Traditional Chinese villages, recognized as national heritage sites, are invaluable cultural assets. Since 2012, efforts have focused on their preservation, though issues remain such as prioritizing authenticity over usability and material over cultural ...
Junjun Li, Jin Wang, Xun Li
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Sustaining urban memory through oyster shell Architecture: constructing an evaluation framework for vernacular heritage Planning in Guangzhou

Journal of Asian Architecture and Building Engineering
This study tackles the preservation of oyster shell walls, a unique Lingnan vernacular architectural heritage, amid Guangzhou’s urbanization. Facing commercial development, material degradation, and cultural identity loss, a systematic evaluation ...
Ruyi Han, Sijia Cai, Xuefei Li, Shawei Zhang, Ge Wang   +4 more
doaj   +1 more source

Freezing and chemical preservatives alter the stable isotope values of carbon and nitrogen of the Asiatic clam (Corbicula fluminea) [PDF]

, 2011
We tested the impacts of most common sample preservation methods used for aquatic sample materials on the stable isotope ratios of carbon and nitrogen in clams, a typical baseline indicator organism for many aquatic food web studies utilising stable ...
Aurélia Martino, B Fry, B Kelly, BJ Peterson, CJ Sweeting, DM Post, Dorothée Kopp, Frédéric Santoul, H Feuchtmayr, HC Sarakinos, J Dannheim, J Syväranta, J Syväranta, Jari Syväranta, KL Bosley, LM Barrow, M Ventura, MM Mullin, MS Edwards, NO Ogawa, Régis Céréghino, S Carabel, S Kaehler   +22 more
core   +5 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Preparation of Composite Preservation Paper Containing Antagonistic Fungi and Its Application on Apple Preservation

Shipin gongye ke-ji
In order to study the properties of composite preservation paper containing antagonistic fungi and the effect of the composite preservation paper on the physiological quality and preservation quality of Gala apples at room temperature, and at the same ...
Yixuan LIU, Hong YUE, Xinyu SI, Menghan ZHOU, Cunkun CHEN, Honglian GUO   +5 more
doaj   +1 more source

Setting people in their environment: plant and animal remains from Anglo-Scandinavian York [PDF]

, 2004
INTRODUCTION: For the past millennium, the inhabitants of the centre of York have, whether hey knew it or not, been living on top of a compost heap in which are preserved all kinds of remains of Anglo-Scandinavian and early post-conquest life.
Hall, A., Kenward, H.
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source