Results 61 to 70 of about 433,325 (294)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Il digitale che diventa archivio. Le fonti on-line per la storia economica italiana
Diacronie. Studi di Storia Contemporanea, 2012 In this paper we will describe the online sources for economic history, underlining how they have been changing the approach to the discipline. First, we will resume quickly the methodology of the economic history and its changes in the last years, then ...
Matteo Troilo (San Benedetto del Tronto, 1976) si è laureato in Storia all’Università di Bologna ed ha ottenuto il dottorato di ricerca in Storia Economica all’Università di Verona. Attualmente è assegnista di ricerca presso la facoltà di Economia di Rimini e di recente è stato visiting fellow alla Wilfrid Laurier University (Ontario – Canada). Si occupa di vari temi di ricerca di storia economica moderna e contemporanea. Ha pubblicato le monografie: Un’economia di famiglia. Strategie patrimoniali e di prestigio sociale degli Aldrovandi di Bologna (secoli XVII-XVIII), Bologna, Il Mulino, 2010; Storia e protagonisti del turismo a San Marino. Un contributo essenziale all’economia della Repubblica, San Marino, Collana sammarinese di studi storici, 2011.
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Metadata for the digital preservation of open data: an identification study
Biblios, 2021 Objective. Research that aims to identify useful metadata standards for the preservation and digital availability of open data according to current literature.. Method.
Victória de Abreu e Silva +1 more
doaj +1 more source
Preserving Privacy in Data Outsourcing [PDF]
, 2011 Privacy requirements have an increasing impact on the realization of modern applications. Commercial and legal regulations demand that privacy guarantees be provided whenever sensitive information is stored, processed, or communicated to external parties. Current approaches encrypt sensitive data, thus reducing query execution efficiency and preventing
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source