Results 61 to 70 of about 1,438,161 (234)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Il digitale che diventa archivio. Le fonti on-line per la storia economica italiana

Diacronie. Studi di Storia Contemporanea, 2012
In this paper we will describe the online sources for economic history, underlining how they have been changing the approach to the discipline. First, we will resume quickly the methodology of the economic history and its changes in the last years, then ...
Matteo Troilo (San Benedetto del Tronto, 1976) si è laureato in Storia all’Università di Bologna ed ha ottenuto il dottorato di ricerca in Storia Economica all’Università di Verona. Attualmente è assegnista di ricerca presso la facoltà di Economia di Rimini e di recente è stato visiting fellow alla Wilfrid Laurier University (Ontario – Canada). Si occupa di vari temi di ricerca di storia economica moderna e contemporanea. Ha pubblicato le monografie: Un’economia di famiglia. Strategie patrimoniali e di prestigio sociale degli Aldrovandi di Bologna (secoli XVII-XVIII), Bologna, Il Mulino, 2010; Storia e protagonisti del turismo a San Marino. Un contributo essenziale all’economia della Repubblica, San Marino, Collana sammarinese di studi storici, 2011.
doaj  

Metadata for the digital preservation of open data: an identification study

Biblios, 2021
Objective. Research that aims to identify useful metadata standards for the preservation and digital availability of open data according to current literature.. Method.
Victória de Abreu e Silva, Márcio Bezerra da Silva   +1 more
doaj   +1 more source

Planning and managing the cost of compromise for AV retention and access [PDF]

, 2012
Long-term retention and access to audiovisual (AV) assets as part of a preservation strategy inevitably involve some form of compromise in order to achieve acceptable levels of cost, throughput, quality, and many other parameters.
addis, barroso, cunningham, jiang, miller, moore, surridge   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Sending your research material into the future [PDF]

, 2012
A leaflet offering practical guidance for researchers on how to preserve their digital research material/data. This is one of the outputs of the JISC SHARD project, investigating research data preservation for history researchers, and related projects in
Collins, Anna, Raggett, Malcolm, Sleeman, Patricia   +2 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source