Results 81 to 90 of about 433,325 (294)

Privacy preservation in self-governing openness of data

open access: yes大数据, 2018
The openness of data is very important for improving the application value of data resource.However,due to the consideration of privacy preservation,data should be open under supervision.That is,data should be in the mode of selfgoverning openness.For ...
Zhihui WANG, Xuchen ZHOU, Yun ZHU
doaj  

Technology of Data: Collection, Communication, Access and Preservation - IASSIST 2008

open access: yesIASSIST Quarterly, 2008
Technology of Data: Collection, Communication, Access and Preservation - IASSIST ...
Editors
doaj   +1 more source

Privacy preserving synthetic health data [PDF]

open access: yes, 2019
We examine the feasibility of using synthetic medical data generated by GANs in the classroom, to teach data science in health informatics. Teaching data analysis with actual medical data such as electronic healthcare records is greatly restrained by laws protecting patient's privacy, such as HIPAA in the United States.
Yale, Andrew   +5 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Preservation of data for Earth system science - Towards a content standard

open access: yes, 2012
Various remote sensing agencies of the world have created a data rich environment for research and applications over the last three decades. Especially over the last decade, the volume and variety of data useful for Earth system science have increased ...
John Moses   +2 more
core   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Data Preservation Plan (DPP)

open access: yes, 2023
First version of ICES Data Preservation plan.A Data Preservation Plan (DPP) outlines a data custodian’s responsibility towards data preservation specified in documentation, including custody transfer, submission information standards, and archival ...
ICES (11907872)
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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