Results 91 to 100 of about 171,070,652 (247)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

International Internet Preservation Consortium Quarterly highlight report: November - December 2010

, 2011
This report summarizes the activities of the International Internet Preservation Consortium Preservation Working Group from the fourth quarter of ...
International Internet Preservation Consortium. Preservation Working Group
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Preservation of Historically and Scientifically Important Geospatial Data From Venus

Earth and Space Science
A large volume of scientifically and historically important data from the early exploration of Venus is not widely available to researchers. Our work is focused on ameliorating this problem with the archival of geospatial data including radar, topography,
T. J. Austin, J. G. O'Rourke, D. M. Nelson   +2 more
doaj   +1 more source

Differential Privacy Preservation for Continuous Release of Real-Time Location Data

Entropy
Continuous real-time location data is very important in the big data era, but the privacy issues involved is also a considerable topic. It is not only necessary to protect the location privacy at each release moment, but also have to consider the impact ...
Lihui Mao, Zhengquan Xu
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Research Data File Formats and Digital Preservation — Final Report [PDF]

, 2017
This report is part of designing the digital preservation ensemble. It focuses on research data file formats, whose understandability, prevalence and software support are important for data reuse.
Digital preservation services development group
core   +1 more source

Community-based Curate-a-Thons to Enhance Preservation of Global Genetic Biodiversity Data

International Journal of Digital Curation
Science, Technology, Engineering, and Mathematics (STEM) and Research Data Librarians collaborated with an international research team of conservation geneticists to create an instructional and practical guide combining genetic biodiversity initiatives ...
Andrea L Pritt, Briana E Wham, Rachel H Toczydlowski, Eric D Crandall   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source