Results 111 to 120 of about 1,438,161 (234)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

ATLAS Data Preservation

Journal of Physics: Conference Series, 2015
Complementary to parallel open access and analysis preservation initiatives, ATLAS is taking steps to ensure that the data taken by the experiment during Run-1 remain accessible and available for future analysis by the collaboration. An evaluation of what is required to achieve this is underway, examining the ATLAS data production chain to establish ...
RWL Jones, DM South, KS Cranmer
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Preservation of Research Data for Reuse.

, 2016
This panel aims to link research and practice around the preservation necessary for meaningful reuse of research data over the long term. Panelists will discuss preserving the contexts around the meaning of data that enable assessments of data quality necessary for reuse, preserving the bits of data that enable long term access across the continuum and
Faniel, Ixchel, Ensberg, Vessela, Shaw, Seth, Hull, Elizabeth, Moore, Reagan   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Towards a framework for predicting whole life-cycle cost for long-term digital preservation [PDF]

, 2013
Estimating the costs for the whole lifecycle of long-term digital preservation (LTDP) activities ena-bles decision makers to choose carefully what data to preserve, duration of preservation and type of preservation techniques best applied for their ...
Badawy, Mohamed, Baguley, Paul, Sanya, Isaac, Shehab, Essam   +3 more
core  

Data Preservation and Long Term Analysis in High Energy Physics

, 2012
Several important and unique experimental high-energy physics programmes at a variety of facilities are coming to an end, including those at HERA, the B-factories and the Tevatron.
South, David M.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Moving data into and out of an institutional repository: Off the map and into the territory [PDF]

, 2007
Given the recent proliferation of institutional repositories, a key strategic question is how multiple institutions - repositories, archives, universities and others—can best work together to manage and preserve research data.
Bishop, Libby
core