Results 71 to 80 of about 195,517 (390)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Risk Assessment of Triclosan, a Cosmetic Preservative

open access: yesToxicological Research, 2019
Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxicology and risk assessment of TCS based on available data.
Jung Dae Lee   +9 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Glaucoma therapy: preservative-free for all?

open access: yesClinical Ophthalmology, 2018
Preservatives used in topical glaucoma medications have a plethora of well-described toxic effects on the ocular surface. Such ocular toxicity is manifest clinically as ocular surface disease (OSD) and has been confirmed in epidemiologic, prospective ...
J. Thygesen
semanticscholar   +1 more source

Scientific Opinion on the safety and efficacy of formaldehyde as a feed hygiene substance in feed for pigs and poultry [PDF]

open access: yesEFSA Journal, 2014
The additive formaldehyde is an aqueous solution of formaldehyde (34–38 % w/w by specification) and methanol (0.5–15.0 % v/v by specification), with a maximum concentration of formic acid of 0.05 %.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Tannin-boron wood preservatives [PDF]

open access: yes, 2011
Tannin-boron wood preservatives are alternative products to replace water-borne formulations based on copper. Interesting results in protection against fungus (pycnoporus sanguineus) were achieved with formulations based of 20% tannin solutions ...
Pizzi, Antonio   +3 more
core  

Invertibility preserving maps preserve idempotents.

open access: yesMichigan Mathematical Journal, 1998
Let \({\mathcal B}\) be a unital norm-closed operator algebra on some complex Banach space such that \({\mathcal B}\) contains all of the finite-rank operators. The main result of the paper under review is that, if \({\mathcal A}\) is a unital Banach algebra and \(\varphi:{\mathcal A}\to{\mathcal B}\) is a unital surjective linear mapping which takes ...
Brešar, Matej, Šemrl, Peter
openaire   +4 more sources

Hip preservation

open access: yesEFORT Open Reviews, 2020
Classical indications for hip preserving surgery are: femoro-acetabular impingement (FAI) (intra- and extra-articular), hip dysplasia, slipped capital femoral epiphysis, residual deformities after Perthes disease, avascular necrosis of the femoral head.
Hanke, Markus S.   +4 more
openaire   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Safety of lactic acid and calcium lactate when used as technological additives for all animal species

open access: yesEFSA Journal, 2017
The additives under assessment are lactic acid and calcium lactate. In 2015, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an Opinion on the safety and efficacy of lactic acid and calcium lactate.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)   +25 more
doaj   +1 more source

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