Results 61 to 70 of about 25,179 (311)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Antibacterial Activity of Conifer Green Needle Complex Against Corynebacteria

Natural Product Communications, 2020
Traditionally, preservatives have been used in cosmetic products to minimize bacterial contamination. Some opportunistic Corynebacterium spp. have become resistant to these preservatives and other alternatives are required.
Vagif S. Soultanov, Lyudmila A. Kraeva
doaj   +1 more source

Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension [PDF]

, 2018
The stability of extemporaneously prepared sodium benzoate oral suspension in cherry syrup and Ora-Sweet was studied. Oral solutions of 250-mg/mL sodium benzoate were prepared in either cherry syrup or Ora-Sweet.
Atkins, Julia, Decker, Andrew S., Hutchinson, David, Lull, Melinda E.   +3 more
core   +1 more source

Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations

Journal of Analytical Methods in Chemistry, 2023
Efficient and resilient techniques for handling samples are essential for detecting pharmaceutical compounds in the environment. This study explores a method for preserving water samples during transport before quantitative analysis. The study investigates the stability of 17α-ethynylestradiol (EE2), acetaminophen (ACM), oxytetracycline (OTC ...
Hidayati, Nuning, Asia, Laurence, Lebarillier, Stephanie, Widowati, Ita, Sabdono, Agus, Piram, Anne, Hidayat, Rizqi, Fitriyah, Dina, Almanar, Indra, Doumenq, Pierre, Syakti, Agung   +10 more
openaire   +4 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Does microbicide use in consumer products promote antimicrobial resistance? A critical review and recommendations for a cohesive approach to risk assessment [PDF]

, 2013
The increasing use of microbicides in consumer products is raising concerns related to enhanced microbicide resistance in bacteria and potential cross resistance to antibiotics.
Bloomfield, Sally, Coelho, Joana Rosado, Collier, Phillip J., Cookson, Barry, Fanning, Séamus, Hartemann, Philippe, Hill, Andrew, Maillard, Jean-Yves, Mcbain, Andrew J., Oggioni, Marco, Sattar, Syed, Schweizer, Herbert P., Threlfall, John   +12 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Characteristics of glaucoma therapy with prostaglandin analogues nowadays [PDF]

Клиническая офтальмология, 2022
I.B. Alekseev1, A.V. Volkova1, L.I. Alekseeva2 1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation 2I.M.
I.B. Alekseev, A.V. Volkova, L.I. Alekseeva   +2 more
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Microbial synthesis of 4-hydroxybenzoic acid from renewable feedstocks

Food Chemistry: Molecular Sciences, 2021
4-Hydroxybenzoic acid (4HBA) and its esterified forms can be used as preservatives in the pharmaceutical and food industries. Here, we reported the establishment of a coenzyme-A (CoA) free multi-enzyme cascade in Escherichia coli to utilize biobased L ...
Yueyang Chen, Yufen Chen, Lijun Liu, Yang Zhang, Jifeng Yuan   +4 more
doaj   +1 more source