Results 51 to 60 of about 24,910 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Antibacterial Activity of Conifer Green Needle Complex Against Corynebacteria

Natural Product Communications, 2020
Traditionally, preservatives have been used in cosmetic products to minimize bacterial contamination. Some opportunistic Corynebacterium spp. have become resistant to these preservatives and other alternatives are required.
Vagif S. Soultanov, Lyudmila A. Kraeva
doaj   +1 more source

Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension [PDF]

, 2018
The stability of extemporaneously prepared sodium benzoate oral suspension in cherry syrup and Ora-Sweet was studied. Oral solutions of 250-mg/mL sodium benzoate were prepared in either cherry syrup or Ora-Sweet.
Atkins, Julia, Decker, Andrew S., Hutchinson, David, Lull, Melinda E.   +3 more
core   +1 more source

Plant nutraceuticals as antimicrobial agents in food preservation: terpenoids, polyphenols and thiols [PDF]

, 2018
This work was supported by a LIBERBANK Retención de Jóvenes Talentos 2014–2015 fellowship to ...
Fernández Fernández, Javier, Gutiérrez del Río Menéndez, Ignacio, Lombó Brugos, Felipe   +2 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Does microbicide use in consumer products promote antimicrobial resistance? A critical review and recommendations for a cohesive approach to risk assessment [PDF]

, 2013
The increasing use of microbicides in consumer products is raising concerns related to enhanced microbicide resistance in bacteria and potential cross resistance to antibiotics.
Bloomfield, Sally, Coelho, Joana Rosado, Collier, Phillip J., Cookson, Barry, Fanning, Séamus, Hartemann, Philippe, Hill, Andrew, Maillard, Jean-Yves, Mcbain, Andrew J., Oggioni, Marco, Sattar, Syed, Schweizer, Herbert P., Threlfall, John   +12 more
core   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Characteristics of glaucoma therapy with prostaglandin analogues nowadays [PDF]

Клиническая офтальмология, 2022
I.B. Alekseev1, A.V. Volkova1, L.I. Alekseeva2 1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation 2I.M.
I.B. Alekseev, A.V. Volkova, L.I. Alekseeva   +2 more
doaj  

Microbial synthesis of 4-hydroxybenzoic acid from renewable feedstocks

Food Chemistry: Molecular Sciences, 2021
4-Hydroxybenzoic acid (4HBA) and its esterified forms can be used as preservatives in the pharmaceutical and food industries. Here, we reported the establishment of a coenzyme-A (CoA) free multi-enzyme cascade in Escherichia coli to utilize biobased L ...
Yueyang Chen, Yufen Chen, Lijun Liu, Yang Zhang, Jifeng Yuan   +4 more
doaj   +1 more source