Results 61 to 70 of about 8,537 (290)

Processing and Properties of Hot-Dip Galvanized Press-Hardening Steels [PDF]

, 2021
Muottikarkaisu on autoteollisuuden käyttämä valmistusmentelmä, jota hyödynnetään henkilöautokorin suojauskomponenttien valmistuksessa. Suorassa muottikarkaisuprosessissa teräsaihio austenoidaan uunissa ja kuumamuovataan sekä karkaistaan muovaustyökalun ...
Järvinen, Henri
core  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Predictive Analysis from numerical and experimental data in press hardening

, 2022
Art. 012060, 9 S.Machine learning, big data and deep learning are today's catchphrases for how to improve reliability and productivity of your manufacturing equipment.
Link, Patrick, Ihlenfeldt, Steffen, Albert, André, Stoll, Anke, Penter, Lars   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Press Hardening of Tubes with Additional Interior Spray Cooling

, 2015
Press-hardened profiles are used e.g. for automotive applications in order to improve light weight construction due to the high reachable strength. The application of interior water-air spray cooling contributes to significantly reducing the cycle time in the production of heat-treated tubes.
B.-A. Behrens, H. J. Maier, A. Neumann, J. Moritz, S. Hübner, T. Gretzki, F. Nürnberger, A. Spiekermeier   +7 more
openaire   +1 more source

Numerical investigation of galling in a press hardening experiment with AlSi-coated workpieces

, 2019
Press hardened steels are commonly used as a lightweight choice for manufacturing car components because of the high ratio of strength to weight. The use of ultra-high-strength steels for the design of lightweight vehicles contributes to the reduction of
Hardell, Jens,, Prakash, Braham,, Oldenburg, Mats,, Pelcastre, Leonardo,, Deng, Liang,   +4 more
core   +1 more source

Press hardening of alternative materials: conventional high- strength steels [PDF]

, 2017
he increase in strength of new high strength steels(HHS) and advanced high strength steels (AHHS) has led toforming issues, such as high springback, low formability, increase of forming forces and tool wear.
Herrero-Dorca, Nuria, GALDOS, Lander, Eneko Saenz de Argandoña, Joseba Mendiguren, Sáenz de Argandoña, Eneko, Lander Galdos, Mendiguren, Joseba, Nuria Herrero-Dorca   +7 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source