Results 81 to 90 of about 8,537 (290)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Recent scientific research on electrothermal metallurgical processes
Записки Горного института, 2019 A wide range of industrial metallurgical heating and melting processes are carried out using electrothermal technologies. The application of electrothermal processes offers many advantages from technological, ecological and economical point of view ...
E. Baake, V. A. Shpenst
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Laser welding properties of 1800 MPa press hardening steel and low-alloy high-strength steel CR340LA
工程科学学报, 2020 A laser tailor welding experiment of 1800 MPa press hardening steel and low-alloy high-strength steel CR340LA was carried out using an optical fiber laser.
Wen LIANG +5 more
doaj +1 more source
, 2016 The present work describes the technological state of the art of press hardening, as well as the main research topics and current developments carried out by a press hardening research cluster in Chemnitz, Germany.
Landgrebe, Dirk +7 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Cailiao gongcheng, 2020 The ultrafine-grained Mg-3Al-Zn alloy was prepared by high energy ball milling,cold vacuum press and warm extrusion. The influence of ball milling time on the microstructure and mechanical properties of the alloy was studied. The results show that Al and
FANG Wa, LI Ji-guang, DU Zheng-yong
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Direct Resistance Joule Heating of Al-10 pct Si-Coated Press Hardening Steel
, 2018 Various rapid heating methods have been developed to increase the productivity of press hardening steel. One of these methods is direct resistance Joule heating.
Lee, CW +3 more
core +2 more sources