Results 71 to 80 of about 8,537 (290)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
MetalsUltra-high-strength steel sheets were joined by forge joining during hot stamping. This study investigated the influence of punch cross-sectional shape and punch tip inclination shape on joint strength through experiments and finite element simulation ...
Jarupong Charoensuk +3 more
doaj +1 more source
, 2014 Tool wear occurring in press hardening processes receives insufficient attention since its corresponding measurements and full-scale experiments are complicated and expensive.
Hardell, Jens, +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
MetalsThis study introduced a pre-holed hot clinching process for hot stamping patchwork blanks, using the lower sheet pre-hole as a forming cavity to facilitate material flow and minimize deformation resistance. Evaluated through mechanical testing and finite
Jarupong Charoensuk +4 more
doaj +1 more source
Alloy Optimization for Reducing Delayed Fracture Sensitivity of 2000 MPa Press Hardening Steel
Metals, 2020 Press hardening steel (PHS) is widely applied in current automotive body design. The trend of using PHS grades with strengths above 1500 MPa raises concerns about sensitivity to hydrogen embrittlement.
Hardy Mohrbacher, Takehide Senuma
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Mechanical Properties of Trip Aided Bainitic Ferrite TBF Steels in Production and Service Conditions
Hittite Journal of Science and Engineering, 2018 I n the automotive industry, one of the most common methods to reduce the weight of the body components is to downgage the sheets using higher strength steels. In the design phase, engineers typically use the material properties of the incoming material,
Eren Billur +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source