Results 81 to 90 of about 8,297,853 (296)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Blood pressure distribution according to [11].

, 2022
Blood pressure distribution according to [11].
Beatrice Vetter (10277861), Sergio Brenner Miguel (14227353), Jennifer Elizabeth Cohn (14227356), Till Baernighausen (12850238), Lisa Koeppel (14227350), Sabine Dittrich (85996), Pascal Geldsetzer (549621), Claudia M. Denkinger (8790434), Sergio Carmona (562195), Stefano Ongarello (4428046)   +9 more
core   +1 more source

Torsobarography: Intra-Observer Reliability Study of a Novel Posture Analysis Based on Pressure Distribution

Sensors
Postural deformities often manifest themselves in a sagittal imbalance and an asymmetric morphology of the torso. As a novel topographic method, torsobarography assesses the morphology of the back by analysing pressure distribution along the torso in a ...
Nico Stecher, Andreas Heinke, Arkadiusz Łukasz Żurawski, Maximilian Robert Harder, Paula Schumann, Thurid Jochim, Hagen Malberg   +6 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Assessing the Diagnostic Validity of Torsobarography in Scoliosis

Sensors
Adolescent idiopathic scoliosis (AIS) is treated with various forms of conservative care or surgery, depending on the degree of severity. When AIS is detected early, it can be monitored and initially treated with reduced invasiveness to prevent further ...
Nico Stecher, Lea Richter, Arkadiusz Łukasz Żurawski, Andreas Heinke, Maximilian Robert Harder, Thurid Jochim, Paula Schumann, Wojciech Piotr Kiebzak, Hagen Malberg   +8 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Behavioural and respiratory response of the shallow-water hermit crab Pagurus cuanensis to hydrostatic pressure and temperature [PDF]

, 2010
The evolutionary history of the Anomura has long been controversially discussed. One aspect that has received little attention is the dissimilarity in physiological tolerances of the related families Paguridae and Lithodidae to environmental conditions ...
Casburn, Laura, Thatje, Sven, Calcagno, Javier A., Calcagno, Javier Ángel   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Fluid flow and heat transfer of a two-dimensional offset jet with a plasma actuator

Nihon Kikai Gakkai ronbunshu, 2017
This study is concerned with the active flow control of a two-dimensional offset jet using a dielectric barrier discharge plasma actuator (PA). The offset jet is produced by the flow of air that issues from the end of a long parallel channel, and the ...
Yusuke NOGI, Masatoshi SANO, Kuniaki TOYODA, Shinji HONAMI   +3 more
doaj   +1 more source