Results 71 to 80 of about 7,952,101 (296)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Pressure Change in a Duct with a Flow of a Homogeneous Gaseous Substance in the Presence of a Point Mass and Momentum Sink of Gas

Energies
The flow characteristics of homogeneous gases in complex systems are an important issue in many areas, including underground mines. The flow in mine excavations and ventilation systems is described by known mathematical relationships that could be ...
Bogusław Ptaszyński, Rafał Łuczak, Zbigniew Kuczera, Piotr Życzkowski, Klaudia Zwolińska-Glądys, Marek Borowski   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Torsobarography: Intra-Observer Reliability Study of a Novel Posture Analysis Based on Pressure Distribution

Sensors
Postural deformities often manifest themselves in a sagittal imbalance and an asymmetric morphology of the torso. As a novel topographic method, torsobarography assesses the morphology of the back by analysing pressure distribution along the torso in a ...
Nico Stecher, Andreas Heinke, Arkadiusz Łukasz Żurawski, Maximilian Robert Harder, Paula Schumann, Thurid Jochim, Hagen Malberg   +6 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assessing the Diagnostic Validity of Torsobarography in Scoliosis

Sensors
Adolescent idiopathic scoliosis (AIS) is treated with various forms of conservative care or surgery, depending on the degree of severity. When AIS is detected early, it can be monitored and initially treated with reduced invasiveness to prevent further ...
Nico Stecher, Lea Richter, Arkadiusz Łukasz Żurawski, Andreas Heinke, Maximilian Robert Harder, Thurid Jochim, Paula Schumann, Wojciech Piotr Kiebzak, Hagen Malberg   +8 more
doaj   +1 more source

Fluid flow and heat transfer of a two-dimensional offset jet with a plasma actuator

Nihon Kikai Gakkai ronbunshu, 2017
This study is concerned with the active flow control of a two-dimensional offset jet using a dielectric barrier discharge plasma actuator (PA). The offset jet is produced by the flow of air that issues from the end of a long parallel channel, and the ...
Yusuke NOGI, Masatoshi SANO, Kuniaki TOYODA, Shinji HONAMI   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Control of two-dimensional offset jet using burst modulation with a plasma actuator

Nihon Kikai Gakkai ronbunshu, 2018
An experimental study is performed on a two-dimensional offset jet with a dielectric barrier discharge plasma actuator (PA) as a flow control device that introduces a periodic disturbance to the system. The offset jet is produced by a flow of air emitted
Shu SASAKI, Masatoshi SANO, Kuniaki TOYODA, Shinji HONAMI   +3 more
doaj   +1 more source