Results 91 to 100 of about 3,964,851 (289)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Development Performance and Pressure Field Evolution of ASP Flooding

Advances in Polymer Technology, 2020
ASP (alkali-surfactant-polymer) is acknowledged as an effective technology to improve the oil recovery. The microscopic displacement efficiency and macroscopic sweep efficiency have been discussed in detail for the past few years.
Junjian Li, Hao Wang, Jinchuan Hu, Hanqiao Jiang, Rongda Zhang, Lihui Tang   +5 more
doaj   +1 more source

Static solutions in Einstein-Chern-Simons gravity

, 2016
In this paper we study static solutions with more general symmetries than the spherical symmetry of the five-dimensional Einstein-Chern-Simons gravity. In this context, we study the coupling of the extra bosonic field $% h^{a}$ with ordinary matter which
Crisóstomo, Juan, Gomez, Fernando, Mella, Patricio, Quinzacara, Cristian, Salgado, Patricio   +4 more
core   +1 more source

Field Measurements of Impact Pressures in Surf

Coastal Engineering 1974, 1974
Field measurements were made of the vertical distribution of impact pressures exerted by breaking waves. Four distinct types are recognized and compared. These are near-breaking wave, plunging breaker, spilling breaker and post-breaking bore. The measurements were obtained by placing a 6 foot aluminum flat plate, backed by a cylinder in the surf zone ...
R.L. Miller, S. Leverette, J. O'Sullivan, J. Tochko, K. Theriault   +4 more
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Experimental study on pressure field of combined well pattern by water flooding

Kuwait Journal of Science, 2018
Pressure field variation was investigated using 3D physical equipment. A vertical well was chosen as injector and two horizontal wells were chosen as producers.
Shidong Wang, Zijian Xu, Yi Pan, Hai Liu, Shuangchun Yang   +4 more
doaj  

Field mapping of ballistic pressure pulse sources

Current Directions in Biomedical Engineering, 2015
Ballistic pressure pulse sources are used since late 1990s for the extracorporeal treatment of chronic Enthesitis. Newly indications are found in trigger-point-therapy for the treatment of musculoskeletal disorders. In both applications excellent results
Rad Abtin Jamshidi, Ueberle Friedrich
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Impact of Magnetic Fields on Arc Pressure, Temperature, Plasma Velocity, and Voltage in TIG Welding

Micromachines
A longitudinal magnetic field provides a new method for regulating the plasma velocity, pressure field, and temperature field of the TIG welding arc. However, the mechanism of action of the longitudinal magnetic field remains poorly understood.
Gang Chen, Gaosong Li, Lei Wu, Zhenya Wang   +3 more
doaj   +1 more source