Results 71 to 80 of about 79,402 (264)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LSTM Reconstruction of Turbulent Pressure Fluctuation Signals

Computation
This paper concerns the application of a long short-term memory model (LSTM) for high-resolution reconstruction of turbulent pressure fluctuation signals from sparse (reduced) data.
Konstantinos Poulinakis, Dimitris Drikakis, Ioannis W. Kokkinakis, S. Michael Spottswood, Talib Dbouk   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Semi-diurnal pressure fluctuation in the ERA40 Data

Meteorologische Zeitschrift, 2007
In a regional analysis the removal of the globally present semi-diurnal pressure signal could be necessary in order to isolate the pressure signal of regional features.
Klaus P. Hoinka
doaj   +1 more source

Experimental study on the flow structure and sound generation between the blades of multi-blade fan

Nihon Kikai Gakkai ronbunshu, 2017
The relationship between flow structure and generation of aerodynamic sound from a multi-blade fan is experimentally investigated with enlarged two-dimensional blade models. Two blade models with different shapes are used.
Koji IWANO, Yusuke GOTO, Yuya FUKAO, Yasuhiko SAKAI, Yasumasa ITO, Koji NAGATA, Masaharu SAKAI, Toshinori OCHIAI, Shuzo ODA   +8 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Study on Pressure Fluctuation Characteristics of Hydraulic Pulsed Jet

Shiyou jixie, 2016
By producing instantaneous negative pressure and pulse shock at the bottomhole,the pulsed jet could reduce the pressure holding effect on the cuttings and improve the efficiency of rock breaking and cutting removing.On the basis of the established ...
Zhang Yi, Li Gensheng, Shi Huaizhong, Wei Minghui   +3 more
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Prediction of Gas–Liquid Two‐Phase Flow Pressure Wave in the Wellbore During the Re‐Production of Deep Gas Wells

Energy Science & Engineering
The pressure of the tube at the wellhead is abruptly released during the opening of a high‐production gas well, causing pressure fluctuation and subjecting the tubing to extra stress.
Yushan Zheng, Shengli Chu, Sixi Zhang, Pengcheng Wang, Yanlong Li, Yinghua Jing, Bingcai Sun, Zhi Zhang, Jiawei Wang   +8 more
doaj   +1 more source