Results 91 to 100 of about 51,789 (323)
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The hodgepodge of rules known as presumptions includes rules of vastly varying importance, rules serving widely divergent purposes, and rules that may construct rules of decision.
Larkin, Murl A.
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The Constitutional Accuracy of Legal Presumptions
This paper is about a century-old yet durably-opaque constitutional doctrine that has the potential to disrupt every field of US law that uses legal presumptions.
Sachin S. Pandya
core +1 more source
"In the field of Defective Narrations or Ahādith Mu'allah, collection and study of chains and tracks have great importance. It is this process in which the difference in the texts and chains of narrations comes to the surface and their defects become ...
Dr. Muhammad Imran , Dr. Mursal Farman
doaj
The Many Faces of "Prima Facie"
The majority of the world’s refugees have secured a legal status without resort to an individual examination of their claims. The practice of “group” determination, particularly in Africa, is interesting in several aspects, not least in that it allows a ...
Jean-François Durieux
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The Law of Presumptions: Essays in Comparative Legal History
The law of presumptions has never been popular among commentators. It has attracted few scholars, and most of the few who have ventured into the subject have come away as critics rather than admirers.
core +1 more source
Note: Burdens of Proof, Presumptions and Standards of Proof in Criminal Cases
In jurisdictions that subscribe to adversarial mode of litigation, burdens and standards of proof have significant roles in the adjudication and determination of criminal cases.
Worku Yaze Wodage
semanticscholar +1 more source

