Results 81 to 90 of about 51,789 (323)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Conclusive Presumptions in West Virginia
, 1959 Presumptions, as might be expected, have been appearing and disappearing throughout the history of evidence. Much confusion has attended the use of the word, and there has been no less confusion about the kinds of presumptions, be they presumptions of ...
R., J. L.
core
Subsequent strabismus surgeries in patients with no prior medical records
Indian Journal of Ophthalmology, 2018 Purpose: To investigate subsequent strabismus surgeries in patients with no prior medical record and to evaluate discrepancies between surgical findings and preoperative presumptions made based on patient self-reporting and clinical findings.
Won Jae Kim, Myung Mi Kim
doaj +1 more source
False Presumptions Counter to the Presumptions of Innocence
Journal of the American Institute of Criminal Law and Criminology, 1917 American criminal procedure is condemned as ineffective, because delay and technicality intervene on behalf of the accused. The sanction of the law is neither swift nor inexorable. Not only do "the wicked flee where no man pursueth," but the prisoner enmeshed is preserved from punishment by over-sedulous respect for his rights. Mr.
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Public Face of Presumptions
, 2008 We commonly think of presumptions as second-best inferential tools allowing us to reach conclusions, if we must, under conditions of limited information.
Petroski, Karen
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A challenge to change developments in feminist theology and feminist Christology
HTS Teologiese Studies/Theological Studies, 2005 Contextual theologies have made it clear that context, and the particular experiences a context gives, shapes thinking about the Divine and the world into a particular, contextual theology.
Riet Bons-Storm
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source