Results 261 to 270 of about 87,423 (320)

The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

open access: yesExperimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti   +6 more
wiley   +1 more source

Direct evidence for ultrastructures of the α-synuclein-associated synaptic vesicle pool in presynaptic terminals

open access: hybrid
Chigure Suzuki   +11 more
openalex   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

open access: yesExperimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova   +6 more
wiley   +1 more source

Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages. [PDF]

open access: yesJ Comp Neurol
Mellott JG   +8 more
europepmc   +1 more source

Use of transcutaneous spinal cord stimulation to explore inhibitory and facilitatory circuits in muscles of the human lower limb

open access: yesExperimental Physiology, EarlyView.
Abstract The aim of this study was to explore the primary afferent depolarization mechanism, to determine whether the soleus transspinal evoked potential (TEP), elicited through transcutaneous spinal cord stimulation over the L1–L2 level, is modulated by presynaptic inhibition and heteronymous facilitation, similar to the Hoffmann (H) reflex, elicited ...
Julia Sordet   +5 more
wiley   +1 more source

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