Results 301 to 310 of about 87,423 (320)
Some of the next articles are maybe not open access.
Presynaptic terminal differentiation: transport and assembly
Current Opinion in Neurobiology, 2004The formation of chemical synapses involves reciprocal induction and independent assembly of pre- and postsynaptic structures. The major events in presynaptic terminal differentiation are the formation of the active zone and the clustering of synaptic vesicles.
Mei, Zhen, Yishi, Jin
openaire +2 more sources
The tipsy terminal: Presynaptic effects of ethanol
Pharmacology & Therapeutics, 2005Considerable evidence suggests that the synapse is the most sensitive CNS element for ethanol effects. Although most alcohol research has focussed on the postsynaptic sites of ethanol action, especially regarding interactions with the glutamatergic and GABAergic receptors, few such studies have directly addressed the possible presynaptic loci of ...
George Robert, Siggins +2 more
openaire +2 more sources
SPARC prevents maturation of cholinergic presynaptic terminals
Molecular and Cellular Neuroscience, 2012Secreted Protein Acidic and Rich in Cysteine (SPARC) is a matricellular protein produced by glial cells. Although it is highly expressed in synaptogenic areas in the developing nervous system, it is still unclear whether this molecule displays an action on synaptic activity. We show that nanomolar concentrations of SPARC favour a more efficient synapse
David, Albrecht +5 more
openaire +2 more sources
Location of calcium transporters at presynaptic terminals
European Journal of Neuroscience, 2000AbstractThe plasma membrane ATP‐driven Ca2+ pump (PMCA) and the Na+/Ca2+ exchanger (NCX) are the major means of Ca2+ extrusion at presynaptic nerve terminals, but little is know about the location of these transporters relative to the major sites of Ca2+ influx, the transmitter release sites.
M, Juhaszova +3 more
openaire +2 more sources
Local translation in presynaptic terminals
Science, 2019Cellular Neuroscience Proteins carry out most of the functions in cells, including neurons, which are one of the most morphologically complex cell types in the body. This poses challenges for how proteins can be supplied to remote regions where connections (synapses) are made with other neurons.
openaire +1 more source
ATP-dependent calcium storage in presynaptic nerve terminals
Nature, 1977CALCIUM ions, which enter presynaptic nerve terminals during depolarisation, trigger transmitter release from the terminals of both peripheral1 and central2 neurones. The subsequent disposition of the entering Ca is not entirely settled. Although this Ca must eventually be extruded in order for the neurones to return to the steady state, some of it may
N C, Kendrick +3 more
openaire +2 more sources
Quantal release of serotonin from presynaptic nerve terminals
Neurochemistry International, 1990Although much is known about the synthesis, storage, break-down and biological importance of serotonin (5-HT) there is little information about its release from presynaptic nerve terminals. For example, in the mammalian CNS it is not known whether 5-HT is released in multimolecular packets (quanta) or whether facilitation of release occurs with ...
J G, Nicholls, D P, Kuffler
openaire +2 more sources
Frontotemporal dementia: Neuropil spheroids and presynaptic terminal degeneration
Annals of Neurology, 1998AbstractWe compared the neuropathological changes of 6 patients with clinically diagnosed lobar dementia. In the 4 patients with histopathology consistent with frontotemporal dementia (FTD), moderate neuronal loss contrasted with marked cortical and subcortical gliosis. We found silver‐positive, carbohydrate‐rich, spheroidal enlargements of presynaptic
L, Zhou +5 more
openaire +2 more sources
The functional landscape of a presynaptic nerve terminal
Cell Calcium, 2012The neuromuscular junction (NMJ) is the original model synapse, and while others have emerged, especially as models of plasticity involving coincidence detectors, the NMJ continues to provide useful new information. It remains, for example, one of the best understood synapses in terms of the relationship between structure and function.
Raquel, Cano +4 more
openaire +2 more sources
Models of the Presynaptic Terminal
1978The preceding three Sections have summarized many of the morphological aspects of current synaptology. In accomplishing this, the ground covered has included conventional synaptic morphology and a range of contemporary approaches to the presynaptic terminal.
openaire +1 more source