Results 151 to 160 of about 1,776 (189)

GPA33-pretargeted radioimmunotherapy with mono- and bivalent DOTA-based Lu-177-labeled radiohaptens in a mouse orthotopic liver xenograft model of metastatic human colorectal cancer. [PDF]

Theranostics
Le Roux AB, Fung EK, Lee SG, Monette S, Xu H, Guo HF, Yang G, Ouerfelli O, Jungbluth A, Schöder H, Larson SM, Cheung NV, Cheal SM, Veach DR.   +13 more
europepmc   +1 more source

Nuclear Imaging of Bispecific Antibodies on the Rise. [PDF]

J Nucl Med
Roohani B, Mendez AS, Dangarwala M, Katz S, Marquez-Nostra B.   +4 more
europepmc   +1 more source

[⁶⁸Ga]Ga-THP-tetrazine for bioorthogonal click radiolabelling: pretargeted PET imaging of liposomal nanomedicines. [PDF]

RSC Chem Biol
Mishra A, Carrascal-Miniño A, Kim J, T M de Rosales R.   +3 more
europepmc   +1 more source

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Pretargeted imaging using bioorthogonal chemistry in mice

Current Opinion in Chemical Biology, 2014
Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy: the tumor targeting of a tagged ...
Raffaella, Rossin, Marc S, Robillard
openaire   +2 more sources

Recent Advances in Pretargeted Imaging of Tumors in Vivo

Analysis & Sensing, 2022
AbstractOver the past decades, the pretargeted strategy has emerged as a promising approach to improve delivery of nucleotides into tumor tissues for nuclear imaging and/or therapy. Unlike conventional nuclear imaging and therapy, in which a radiolabeled tumor targeting vector (e.
Zheng Huang, Yuxuan Hu, Yanling Yang, Weijing Huang, Yuqi Wang, Deju Ye   +5 more
openaire   +1 more source

Development of an enzymatic pretargeting strategy for dual-modality imaging

Chemical Communications, 2015
An in vitro pretargeted imaging strategy based on the HaloTag enzyme is described. Dual-modality (SPECT and optical) HaloTag ligands enable the detection of HER2 expression.
J. C. Knight, M. Mosley, M. R. L. Stratford, H. T. Uyeda, H. A. Benink, M. Cong, F. Fan, S. Faulkner, B. Cornelissen   +8 more
openaire   +4 more sources

Evaluation of Tetrazine Tracers for Pretargeted Imaging within the Central Nervous System

Bioconjugate Chemistry, 2023
The pretargeting approach separates the biological half-life of an antibody from the physical half-life of the radioisotope label, providing a strategy for reducing the radiation burden. A widely explored pretargeting approach makes use of the bioorthogonal click reaction between tetrazines (Tzs) and trans-cyclooctenes (TCOs), combining the targeting ...
Martin R. Edelmann, Christoph Bredack, Sara Belli, Peter Mohr, Marie-Paule Imhoff, Flore Reggiani, Eric A. Kusznir, Arne C. Rufer, Daniel P. Holt, Heather Valentine, Dean F. Wong, Robert F. Dannals, Michael Honer, Luca C. Gobbi   +13 more
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Melanoma imaging with pretargeted bivalent bacteriophage.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007
Random bacteriophage (phage) display peptide libraries have traditionally been used for the selection of clones that bind specific tissues, tumors, and antigens. However, once the targeting peptide is synthetically produced, it often displays a lower affinity than the original phage because of a lack of avidity effects and removal from the virion ...
Jessica R, Newton, Yubin, Miao, Susan L, Deutscher, Thomas P, Quinn   +3 more
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Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody

Nature Medicine, 2005
Here we describe molecular imaging of cancer using signal amplification of a radiotracer in situ by pretargeting a multivalent, bispecific antibody to carcinoembryonic antigen (CEA), which subsequently also captures a radioactive hapten-peptide. Human colon cancer xenografts as small as approximately 0.15 g were disclosed in nude mice within 1 h of ...
Robert M, Sharkey, Thomas M, Cardillo, Edmund A, Rossi, Chien-Hsing, Chang, Habibe, Karacay, William J, McBride, Hans J, Hansen, Ivan D, Horak, David M, Goldenberg   +8 more
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A 3-step pretargeting strategy to image infection.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2001
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Boerman, O.C., Eerd-Vismale, J.E.M. van, Oyen, W.J.G., Corstens, F.H.M.   +3 more
openaire   +3 more sources