Results 151 to 160 of about 410,516 (265)

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Integrated microwave-assisted acetic acid pretreatment and endoglucanase-xylanase hydrolysis for nanocrystalline cellulose preparation. [PDF]

MethodsX
Lim KY, Foo KY.
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Hydroxymethylfurfural Formation and Sensory Implications in Raisins: Effects of Cultivar, Extra Virgin Olive Oil Pretreatment, and Storage Temperature. [PDF]

Plants (Basel)
Shimizu-Marin VD, Bruno DH, Nishiyama-Hortense YP, Olivati C, Lago-Vanzela ES.   +4 more
europepmc   +1 more source

A Foundation Model Based CT Biomarker for Non‐Invasive Prediction of Response to Neoadjuvant Immunochemotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study introduces a foundation model‐based biomarker for risk stratification of pathological response in non‐small cell lung cancer. A Vision Mamba super‐resolution model standardizes heterogeneous CT images. A multi‐task Swin Transformer then fine‐tunes a pre‐trained lung foundation model to jointly optimize tumor segmentation and response ...
Yanglan Xu, Shuchang Zhou, Qin Peng, Xiao Bao, Xiaodan Ye, Ahmet Görkem Er, Tong Tong, Mirabela Rusu, Yajia Gu, Mailin Chen, Jing Gong   +10 more
wiley   +1 more source

Genistein Pretreatment Attenuates Ovalbumin-Induced Food Allergy in Mice with Intestinal Barrier Preservation and Modulation of Gut Microbiota and Metabolites. [PDF]

Foods
Yi X, Deng W, Gao K, Ou X, Tang K, Zeng Q, Ni Y, Liang X, Wu Z, Wu Y, Xie Y, Chen H, Yang A.   +12 more
europepmc   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Effects of combined ultrasonic and microwave pretreatments on vacuum freeze-drying efficiency and quality of giant freshwater prawn (<i>Macrobrachium rosenbergii</i>). [PDF]

Food Chem X
Yuan R, Xiong Z, Yuan L, Jin W, Jiang L, Gao R.   +5 more
europepmc   +1 more source

Thermally Processable, Transparent, Mechanically Tunable and Robust Bioplastics From Wastepaper

Advanced Science, EarlyView.
Unlike conventional inefficient or low‐value wastepaper recycling, a directional transformation strategy is employed to convert whole wastepaper into intact bioplastics with tunable mechanical properties in our work. These bioplastics can be processed into flexible bags or rigid containers and exhibit high transparency, water resistance, repairability,
Zhezhe Zhou, Tao Chu, Boyou Hou, Mark Lynch, Siqi Huo, Min Hong, Jianguo Yang, Paulomi (Polly) Burey, Qiang Gao, Guobo Huang, Pingan Song   +10 more
wiley   +1 more source

Prognostic impact of MRI-based cervical skeletal muscle mass on survival in parotid gland carcinoma. [PDF]

Jpn J Clin Oncol
Kasahara K, Mikoshiba T, Idei K, Matsui Y, Kono T, Sekimizu M, Ozawa H.   +6 more
europepmc   +1 more source