Results 91 to 100 of about 4,277,975 (337)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi +18 morewiley +1 more sourceSystematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow +10 morewiley +1 more sourceComprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi +11 morewiley +1 more sourceEstimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
Lancet Public Health, 2022 Emma Jaimie D Stein Emil Kai Julian Foad Amir Ahmed Ema Nichols Steinmetz Vollset Fukutaki Chalek Abd-Alla, E. Nichols, Jaimie D Steinmetz, S. Vollset, K. Fukutaki, Julian Chalek, F. Abd-Allah, Amir Abdoli, Ahmed Abualhasan, Eman Abu-Gharbieh, Tayyaba Akram, Hanadi Al Hamad, F. Alahdab, Fahad Mashhour Alanezi, V. Alipour, Sami A. Almustanyir, Hubert Amu, Iman Ansari, J. Arabloo, T. Ashraf, T. Astell‐Burt, G. Ayano, J. Ayuso-Mateos, A. Baig, A. Barnett, Amadou Barrow, B. Baune, Y. Béjot, Woldesellassie M. Bezabhe, Y. Bezabih, A. Bhagavathula, S. Bhaskar, Krittika Bhattacharyya, Ali Bijani, Atanu Biswas, S. Bolla, A. Boloor, C. Brayne, H. Brenner, K. Burkart, R. Burns, L. Cámera, C. Cao, F. Carvalho, Luis F. S. Castro-de-Araujo, F. Catalá-López, E. Cerin, Prachi P. Chavan, N. Cherbuin, D. Chu, V. M. Costa, Rosa A A Couto, O. Dadras, X. Dai, L. Dandona, R. Dandona, Vanessa De la Cruz-Góngora, Deepak Dhamnetiya, D. Dias da Silva, Daniel Diaz, A. Douiri, D. Edvardsson, Michael Ekholuenetale, Iman El Sayed, S. El-Jaafary, K. Eskandari, S. Eskandarieh, S. Esmaeilnejad, Jawad Fares, Andre Faro, U. Farooque, V. Feigin, Xiaoqi Feng, S. Fereshtehnejad, E. Fernandes, P. Ferrara, I. Filip, H. Fillit, F. Fischer, Shilpa Gaidhane, L. Galluzzo, A. Ghashghaee, N. Ghith, A. Gialluisi, S. Gilani, I. Glăvan, E. Gnedovskaya, Mahaveer Golechha, R. Gupta, Veer Bala Gupta, Vivek Kumar Gupta, M. R. Haider, B. Hall, S. Hamidi, Asif Hanif, G. Hankey, S. Haque, R. K. Hartono, Ahmed I Hasaballah, M. Hasan, Amr Hassan, Simon Iain Hay, K. Hayat, M. Hegazy, G. Heidari, R. Heidari-Soureshjani, C. Herteliu, Mowafa J Househ, R. Hussain, B. Hwang, L. Iacoviello, I. Iavicoli, O S Ilesanmi, I. Ilic, M. Ilic, S. Irvani, Hiroyasu Iso, M. Iwagami, Roxana Jabbarinejad, L. Jacob, Vardhmaan Jain, Sathish Kumar Jayapal, R. Jayawardena, Ravi Prakash Jha, J. Jonas, N. Joseph, Rizwan Kalani, Amit Kandel, Himal Kandel, A. Karch, Ayele Semachew Kasa, G. M. Kassie, P. Keshavarz, Moien A. B. Khan, M. Khatib, T. Khoja, J. Khubchandani, Min Seo Kim, Y. Kim, A. Kisa, S. Kisa, M. Kivimäki, W. Koroshetz, A. Koyanagi, G. Kumar, Manasi Kumar, H. Lak, M. Leonardi, Bingyu Li, Stephen S. Lim, Xuefeng Liu, Yuewei Liu, G. Logroscino, S. Lorkowski, G. Lucchetti, Ricardo Lutzky Saute, F. Magnani, A. A. Malik, J. Massano, M. Mehndiratta, R. Menezes, A. Meretoja, B. Mohajer, Norlinah Mohamed Ibrahim, Y. Mohammad, Arif Mohammed, A. Mokdad, S. Mondello, M. A. Moni, M. Moniruzzaman, T. B. Mossie, G. Nagel, Muhammad Naveed, Vinod C. Nayak, Sandhya Neupane Kandel, T. H. Nguyen, Bogdan Oancea, Nikita Otstavnov, Stanislav S. Otstavnov, M. Owolabi, S. Panda‐Jonas, Fatemeh Pashazadeh Kan, Maja Pašović, U. Patel, M. Pathak, M. F. Peres, Arokiasamy Perianayagam, C. Peterson, M. Phillips, Marina Pinheiro, M. Piradov, C. Pond, Michele H. Potashman, F. Pottoo, S. Prada, A. Radfar, A. Raggi, F. Rahim, Mosiur Rahman, Pradhum Ram, P. Ranasinghe, D. Rawaf, S. Rawaf, N. Rezaei, A. Rezapour, S. Robinson, M. Romoli, G. Roshandel, R. Sahathevan, A. Sahebkar, M. Sahraian, B. Sathian, D. Sattin, M. Sawhney, Mete Saylan, S. Schiavolin, Allen Seylani, F. Sha, M. Shaikh, K. Shaji, Mohammed Shannawaz, J. Shetty, M. Shigematsu, J. Shin, R. Shiri, D. Silva, J. Silva, Renata Silva, Jasvinder A. Singh, V. Skryabin, A. Skryabina, Amanda E. Smith, S. Soshnikov, E. Spurlock, Dan J Stein, Jing Sun, R. Tabarés-Seisdedos, B. Thakur, Binod Timalsina, M. Tovani-Palone, B. Tran, Gebiyaw Wudie Tsegaye, Sahel Valadan Tahbaz, Pascual Valdez, N. Venketasubramanian, V. Vlassov, G. Vu, L. G. Vu, Yuanqiang Wang, A. Wimo, A. Winkler, Lalit Yadav, Seyed Hossein Yahyazadeh Jabbari, K. Yamagishi, Lin F. Yang, Y. Yano, N. Yonemoto, Chuanhua Yu, Ismaeel Yunusa, S. Zadey, M. Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, C. Murray, T. Vos +264 moresemanticscholar +1 more sourceGenomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text
Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton +19 morewiley +1 more sourcePrevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Journal of the American Medical Association (JAMA), 2004 CONTEXT
The prevalence of overweight and obesity has increased markedly in the last 2 decades in the United States.
OBJECTIVE
To update the US prevalence estimates of overweight in children and obesity in adults, using the most recent national data of ...Allison A. Hedley, Cynthia L Ogden, C. Johnson, M. Carroll, L. Curtin, K. Flegal +5 moresemanticscholar +1 more sourceA nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun +13 morewiley +1 more source
