Results 91 to 100 of about 7,501,773 (380)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Hypertrophic cardiomyopathy due to truncating variants in myosin binding protein C: a Spanish cohort

Open Heart
Background Hypertrophic cardiomyopathy (HCM) is an inherited disorder whose causal variants involve sarcomeric protein genes. One of these is myosin-binding protein C (MYBPC3), being previously associated with a favourable prognosis.
Carles Díez-López, María Luisa Peña-Peña, Hector Bueno, Fernando Arribas Ynsaurriaga, Vicente Climent-Payá, Maria Melendo-Viu, Rafael Salguero-Bodes, María Valverde-Gómez, Jose María Larrañaga-Moreira, Roberto Barriales, Javier Limeres Freire, Pablo Garcia Pavia, Tomas Ripoll, Maria Gallego Delgado, Esther Zorio, Francisco José Bermudez Jimenez, José Manuel García-Pinilla, Irene Méndez Fernández, Maria Sabater-Molina, Ana Perez Asensio, Álvaro Marchán-Lopez, Julián A Palomino Doza   +21 more
doaj   +1 more source

Prevalence of depression among infertile couples in Iran: A meta-analysis study [PDF]

, 2013
Background: Several studies have been conducted in Iran in order to investigate the prevalence of depression among infertile couples. However, there is a remarkable diversity among the results.
Keramat, A., Masoumi, S.Z., Moosavi, S.A., Poorolajal, J.   +3 more
core   +1 more source

Wastewater workers and hepatitis A virus infection. [PDF]

, 2009
The main occupational hazard of wastewater workers (WWs) is the direct exposure to the variety of infectious agents present in sewage material, with hepatitis A virus (HAV) being the most frequent one.
CACACE, GIANLUCA, MONTUORI, PAOLO, NEGRONE, MARIO, TRIASSI, MARIA   +3 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori [PDF]

, 2000
Background & Aims:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer.
El–Nujumi, Adil, El–Omar, Emad M., Fullarton, Grant, Gillen, Derek, McColl, Kenneth E.L., Murray, Lilian S., Oien, Karin, Williams, Craig, Wirz, Angela   +8 more
core   +1 more source

PREVALENCE OF SCURVY. [PDF]

The Lancet
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openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Impact of the Noninvasive Diagnostic Algorithm on Clinical Presentation and Prognosis in Cardiac Amyloidosis

JACC: Advances
Background: The introduction of a noninvasive diagnostic algorithm in 2016 led to increased awareness and recognition of cardiac amyloidosis (CA). Objectives: The purpose of this study was to analyze the impact of the introduction of the noninvasive ...
Giacomo Tini, MD, Ernesto Cristiano, MD, Mattia Zampieri, MD, Alberto Ponziani, MD, Aldostefano Porcari, MD, Margherita Zanoletti, MD, Carlotta Mazzoni, MD, Matteo Sclafani, MD, Giulia Saturi, MD, Andrea Lalario, MD, Marianna Eleonora Labate, MD, Camillo Autore, MD, Emanuele Barbato, MD, Federico Perfetto, MD, Elena Biagini, MD, Gianfranco Sinagra, MD, Marco Canepa, MD, Marco Merlo, MD, Simone Longhi, MD, Francesco Cappelli, MD, Beatrice Musumeci, MD   +20 more
doaj   +1 more source

Presence of SARS-Coronavirus-2 RNA in Sewage and Correlation with Reported COVID-19 Prevalence in the Early Stage of the Epidemic in The Netherlands

Environmental Science and Technology Letters, 2020
In the current COVID-19 pandemic, a significant proportion of cases shed SARS-Coronavirus-2 (SARS-CoV-2) with their faeces. To determine if SARS-CoV-2 RNA was present in sewage during the emergence of COVID-19 in The Netherlands, sewage samples of six ...
G. Medema, L. Heijnen, G. Elsinga, R. Italiaander, A. Brouwer   +4 more
semanticscholar   +1 more source