Results 111 to 120 of about 7,501,773 (380)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text
Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton +19 morewiley +1 more sourceUnique Features of Cardiovascular Involvement and Progression in Children with Marfan Syndrome Justify Dedicated Multidisciplinary Care
Journal of Cardiovascular Development and DiseaseMarfan syndrome (MIM: # 154700; MFS) is an autosomal dominant disease representing the most common form of heritable connective tissue disorder. The condition presents variable multiorgan expression, typically involving a triad of cardiovascular, eye ...Anwar Baban, Giovanni Parlapiano, Marianna Cicenia, Michela Armando, Alessio Franceschini, Concettina Pacifico, Arianna Panfili, Gaetano Zinzanella, Antonino Romanzo, Adelaide Fusco, Martina Caiazza, Gianluigi Perri, Lorenzo Galletti, Maria Cristina Digilio, Paola Sabrina Buonuomo, Andrea Bartuli, Antonio Novelli, Massimiliano Raponi, Giuseppe Limongelli +18 moredoaj +1 more sourceAre fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water [PDF]
, 2015 Background
While previous research has suggested that there is an association between fluoride ingestion and the incidence of hypothyroidism, few population level studies have been undertaken.Bath, Chana, Cooper, D Lowery, Day, European Commission, Feltman, Flynn, Galletti, Gillam, Harrison, Jooste, Klein, Larsen, Lee, National Research Council (NRC), Peckham, S Peckham, S Spencer, Vanderpump, Vanderpump, Warren, Wilson +22 morecore +1 more sourceEstimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
Lancet Public Health, 2022 Emma Jaimie D Stein Emil Kai Julian Foad Amir Ahmed Ema Nichols Steinmetz Vollset Fukutaki Chalek Abd-Alla, E. Nichols, Jaimie D Steinmetz, S. Vollset, K. Fukutaki, Julian Chalek, F. Abd-Allah, Amir Abdoli, Ahmed Abualhasan, Eman Abu-Gharbieh, Tayyaba Akram, Hanadi Al Hamad, F. Alahdab, Fahad Mashhour Alanezi, V. Alipour, Sami A. Almustanyir, Hubert Amu, Iman Ansari, J. Arabloo, T. Ashraf, T. Astell‐Burt, Getinet Ayano, J. Ayuso-Mateos, A. Baig, A. Barnett, Amadou Barrow, B. Baune, Y. Béjot, Woldesellassie M. Bezabhe, Y. Bezabih, A. Bhagavathula, S. Bhaskar, Krittika Bhattacharyya, Ali Bijani, Atanu Biswas, S. Bolla, A. Boloor, C. Brayne, H. Brenner, K. Burkart, R. Burns, L. Cámera, C. Cao, F. Carvalho, Luis F. S. Castro-de-Araujo, F. Catalá-López, E. Cerin, Prachi P. Chavan, N. Cherbuin, D. Chu, V. M. Costa, Rosa A A Couto, O. Dadras, X. Dai, L. Dandona, R. Dandona, Vanessa De la Cruz-Góngora, Deepak Dhamnetiya, D. Dias da Silva, Daniel Diaz, A. Douiri, D. Edvardsson, Michael Ekholuenetale, Iman El Sayed, S. El-Jaafary, K. Eskandari, S. Eskandarieh, S. Esmaeilnejad, Jawad Fares, Andre Faro, U. Farooque, V. Feigin, Xiaoqi Feng, S. Fereshtehnejad, E. Fernandes, P. Ferrara, I. Filip, H. Fillit, F. Fischer, Shilpa Gaidhane, L. Galluzzo, A. Ghashghaee, N. Ghith, A. Gialluisi, S. Gilani, I. Glăvan, E. Gnedovskaya, Mahaveer Golechha, R. Gupta, Veera Gupta, V. Gupta, M. R. Haider, B. Hall, S. Hamidi, Asif Hanif, G. Hankey, S. Haque, R. K. Hartono, Ahmed I Hasaballah, M. Hasan, Amr Hassan, Simon Iain Hay, K. Hayat, M. Hegazy, G. Heidari, R. Heidari-Soureshjani, C. Herteliu, Mowafa J Househ, R. Hussain, B. Hwang, L. Iacoviello, I. Iavicoli, O S Ilesanmi, I. Ilic, M. Ilic, S. Irvani, Hiroyasu Iso, M. Iwagami, Roxana Jabbarinejad, L. Jacob, Vardhmaan Jain, Sathish Kumar Jayapal, R. Jayawardena, Ravi Prakash Jha, J. Jonas, N. Joseph, Rizwan Kalani, Amit Kandel, Himal Kandel, A. Karch, Ayele Semachew Kasa, G. M. Kassie, P. Keshavarz, Moien A. B. Khan, M. Khatib, T. Khoja, J. Khubchandani, Min Seo Kim, Y. Kim, A. Kisa, S. Kisa, M. Kivimäki, W. Koroshetz, A. Koyanagi, G. Kumar, Manasi Kumar, H. Lak, M. Leonardi, Bingyu Li, Stephen S. Lim, Xuefeng Liu, Yuewei Liu, G. Logroscino, S. Lorkowski, G. Lucchetti, Ricardo Lutzky Saute, F. Magnani, A. A. Malik, J. Massano, M. Mehndiratta, R. Menezes, A. Meretoja, B. Mohajer, Norlinah Mohamed Ibrahim, Y. Mohammad, Arif Mohammed, A. Mokdad, S. Mondello, M. A. Moni, M. Moniruzzaman, T. B. Mossie, G. Nagel, Muhammad Naveed, Vinod C. Nayak, Sandhya Neupane Kandel, T. H. Nguyen, Bogdan Oancea, Nikita Otstavnov, Stanislav S. Otstavnov, M. Owolabi, S. Panda‐Jonas, Fatemeh Pashazadeh Kan, Maja Pašović, U. Patel, M. Pathak, M. F. Peres, Arokiasamy Perianayagam, C. Peterson, M. Phillips, Marina Pinheiro, M. Piradov, C. Pond, Michele H. Potashman, F. Pottoo, S. Prada, A. Radfar, A. Raggi, F. Rahim, Mosiur Rahman, Pradhum Ram, P. Ranasinghe, D. Rawaf, S. Rawaf, N. Rezaei, A. Rezapour, S. Robinson, M. Romoli, G. Roshandel, R. Sahathevan, A. Sahebkar, M. Sahraian, B. Sathian, D. Sattin, M. Sawhney, Mete Saylan, S. Schiavolin, Allen Seylani, F. Sha, M. Shaikh, K. Shaji, Mohammed Shannawaz, J. Shetty, M. Shigematsu, J. Shin, R. Shiri, D. Silva, J. Silva, Renata Silva, Jasvinder A. Singh, V. Skryabin, A. Skryabina, Amanda E. Smith, S. Soshnikov, E. Spurlock, Dan J Stein, Jing Sun, R. Tabarés-Seisdedos, B. Thakur, Binod Timalsina, M. Tovani-Palone, B. Tran, Gebiyaw Wudie Tsegaye, Sahel Valadan Tahbaz, Pascual Valdez, N. Venketasubramanian, V. Vlassov, G. Vu, L. G. Vu, Yuanqiang Wang, A. Wimo, A. Winkler, Lalit Yadav, Seyed Hossein Yahyazadeh Jabbari, K. Yamagishi, Lin F. Yang, Y. Yano, N. Yonemoto, Chuanhua Yu, Ismaeel Yunusa, S. Zadey, M. Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, C. Murray, T. Vos +264 moresemanticscholar +1 more sourceA nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun +13 morewiley +1 more sourceAppropriate time interval to update ambiguous genetic diagnosis in inherited arrhythmogenic syndromes
iScienceSummary: Genetic analysis identified the cause of the disease in inherited arrhythmogenic syndromes. A clinically actionable genetic diagnosis requires an accurate interpretation following the current guidelines. Practically half of the genetic diagnoses Estefanía Martínez-Barrios, Andrea Greco, Sergi Cesar, Carles Díez-López, José Cruzalegui, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Irene Zschaeck, Simone Grassi, Antonio Oliva, Norma Balderrábano, Rocío Toro, Georgia Sarquella-Brugada, Oscar Campuzano +14 moredoaj +1 more sourceThe contribution of genetics to the understanding and management of cardiomyopathies: Part 2
Revista Portuguesa de CardiologiaCardiomyopathies may present as a manifestation of various inherited syndromes. Recognizing the rarity and diagnostic challenges of syndromic and metabolic cardiomyopathies is crucial, as their identification holds significant implications for targeted ...Isabel Cardoso, Mafalda Melo, Pedro Brás, José Miguel Viegas, Inês Almeida, Sofia Nunes, Inês Custódio, Conceição Trigo, Sérgio Laranjo, Rafael Graça, Rui Cruz Ferreira, Mário Oliveira, Sílvia Aguiar Rosa, Diana Antunes +13 moredoaj +1 more source
