Results 111 to 120 of about 6,109,166 (291)

Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger [PDF]

, 2022
Ibrahima Issa, Lamine Mahaman Moustapha, Véronique Hubert, Amadou Ilagouma, Eric Adéhossi, Aboubacar Mahamadou, Neil F. Lobo, Demba Sarr, Lisa M. Shollenberger, Sandrine Houzé, Ronan Jambou, Ibrahim Maman Laminou   +11 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Blood Biomarkers Predict 10-Year Clinical Outcomes in Adult Patients With Congenital Heart Disease

JACC: Advances
Background: The adult congenital heart disease (ACHD) population is growing and risk prediction is important to predict adverse outcome and consult patients during their lifecourse.
Paul M. Hendriks, MSc, MD, Annemien E. van den Bosch, MD, PhD, Laurie W. Geenen, MSc, MD, PhD, Vivan J.M. Baggen, MD, PhD, Jannet A. Eindhoven, MD, PhD, Robert M. Kauling, MD, Judith A.A.E. Cuypers, MD, PhD, Eric Boersma, PhD, Jolien W. Roos-Hesselink, MD, PhD   +8 more
doaj   +1 more source

Toric implantable collamer lens for keratoconus

Indian Journal of Ophthalmology, 2013
Keratoconus is a progressive non-inflammatory thinning of the cornea that induces myopia and irregular astigmatism and decreases the quality of vision due to monocular diplopia, halos, or ghost images.
Mathew Kurian Kummelil, M S Hemamalini, Ridhima Bhagali, Koushik Sargod, Somshekar Nagappa, Rohit Shetty, Bhujang K Shetty   +6 more
doaj   +1 more source

Prevalence of frailty and contributory factors in three Chinese populations with different socioeconomic and healthcare characteristics [PDF]

, 2015
Jean Woo, Zheng Zheng, Jason Leung, Piu Chan   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Basic principles of genetics and genetic counselling

Indian Pacing and Electrophysiology Journal
Genetic counselling and testing is a fast growing field in modern medicine. Genetic analysis can aid in the diagnosis, treatment, management and prevention of (genetic) diseases in patients.
Nina J. Beelen, Jitendra Vohra, Job A.J. Verdonschot   +2 more
doaj   +1 more source

Treating Rheumatoid Arthritis yesterday and today [PDF]

, 2004
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that mainly affects joints. It is the most common form of inflammatory joint disease, and the second commonest joint disease, osteoarthritis being the commonest.
Mallia, Carmel
core  

Incidence of Trypanosoma cruzi infection in two Guatemalan communities.

, 2004
The prevalence of human infection by Trypanosoma cruzi was assessed using an enzyme-linked immunosorbent assay (ELISA) in a serological survey in 1998 of 2 rural communities (SMH and PS) in Guatemala.
Davies, C, Lines, J, Monroy, C, Paz-Bailey, G, Rodas, A, Rosales, R, Tabaru, R   +6 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source