Results 51 to 60 of about 683,936 (256)

Brain neurovascular unit biomarkers: a hypothesis-driven paradigm to advance understanding of post-cardiac arrest cerebral injury

Annals of Intensive Care
Purpose of review: To examine the pathophysiology of cerebral complications following cardiac arrest, to summarise the current state of neurological prognostication, and to explore, as a hypothesis-driven paradigm, how the biological signature of brain ...
Mathieu Bellal, Suzanne Goursaud, Marina Rubio, Olivier Martinaud, Denis Vivien, Damien Du Cheyron, Cédric Daubin   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Digital arrest in the cyber age: a psychological perspective on fear, authority, and consciousness

Frontiers in Psychology
Digital arrest is an emerging form of cyber deception wherein cybercriminals impersonate law enforcement or other authorities to falsely claim legal authority to arrest individuals through digital means, often via phone calls or online communication ...
S. James Robert, Varsha Singh, Ravi P. Pandey, Bismirty Bhuyan   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ethyl Acetate Fraction of Moringa oleifera Leaves Induces Cell Cycle Arrest on T47D Breast Cancer Cell via G0/G1 through Cyclin D1 Expression

Jurnal Kimia Valensi, 2020
Cancer is a disease that is the leading cause of death worlwide. Exploration of a natural product containing anticancer agent provides a promising line for research on cancer.
Riza Apriani, Tati Herlina, Shabarni Gaffar   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Închisoarea noastră cea de toate zilele. Despre pedepse și alte sancțiuni [PDF]

Forum Juridic, 2020
Starting with the harsh consequences of the lockdown, the paper looks into the typology of sanctions. Despite their resemblance in the form of restrictions brought to personal freedom, penalties are different to preventive measures or safety policies. As
Radu Rizoiu
doaj  

Assessing maintenance contracts when preventive maintenance is outsourced [PDF]

, 2012
In some companies, corrective maintenance is conducted in-house but preventive maintenance might be outsourced. This raises a need to optimise some parameters such as the number of contracts from a perspective of the equipment owner.
Shaomin Wu, Wu, Shaomin
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source