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The molecular architecture of cell cycle arrest
Molecular Systems Biology, 2022 The cellular decision governing the transition between proliferative and arrested states is crucial to the development and function of every tissue. While the molecular mechanisms that regulate the proliferative cell cycle are well established, we know ...
Wayne Stallaert +10 more
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VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells [PDF]
Cell Reports, 2021 Summary: The formation of new vessels requires a tight synchronization between proliferation, differentiation, and sprouting. However, how these processes are differentially activated, often by neighboring endothelial cells (ECs), remains unclear.
Ayelet Jerafi-Vider +8 more
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Mechanisms of Cell Cycle Arrest and Apoptosis in Glioblastoma [PDF]
Biomedicines, 2022 Cells of glioblastoma, the most frequent primary malignant brain tumor, are characterized by their rapid growth and infiltration of adjacent healthy brain parenchyma, which reflects their aggressive biological behavior. In order to maintain their excessive proliferation and invasion, glioblastomas exploit the innate biological capacities of the ...
Konstantinos Gousias
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G2/M cell cycle arrest in the life cycle of viruses
Virology, 2007 There is increasing evidence that viral infection, expression of viral protein or the presence of viral DNA causes the host cell cycle to arrest during G2/M. The mechanisms used by viruses to cause arrest vary widely; some involve the activation of the cellular pathways that induce arrest in response to DNA damage, while others use completely novel ...
John Doorbar
exaly +3 more sources
Growth inhibition by fusidic acid in cervical, thyroid, and breast carcinoma cell lines [PDF]
Obstetrics & Gynecology Science, 2023 Objective We investigated the effects of fusidic acid (FA) on human cervical, thyroid, and breast carcinoma cell lines to determine the potential usefulness of FA in cancer treatment.
Jin Young Kim +5 more
doaj +1 more source
Respiratory syncytial virus matrix protein induces lung epithelial cell cycle arrest through a p53 dependent pathway. [PDF]
PLoS ONE, 2012 Respiratory syncytial virus (RSV) is the major cause of viral respiratory infections in children. Our previous study showed that the RSV infection induced lung epithelial cell cycle arrest, which enhanced virus replication.
Tao Bian +3 more
doaj +1 more source
FGF19 induces the cell cycle arrest at G2-phase in chondrocytes
Cell Death Discovery, 2023 Fibroblast growth factor 19 (FGF19) has appeared as a new possible avenue in the treatment of skeletal metabolic disorders. However, the role of FGF19 on cell cycle progression in skeletal system is poorly understood.
Hao Chen +6 more
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Vaccinia Virus Arrests and Shifts the Cell Cycle [PDF]
Viruses, 2021 ABSTRACT Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA damage response.
Caroline K. Martin +6 more
openaire +5 more sources
A Mini-Review on Cell Cycle Regulation of Coronavirus Infection
Frontiers in Veterinary Science, 2020 Coronaviruses are widespread in nature and infect humans, mammals and poultry. They cause harm to humans and animals. Virus-mediated cell cycle arrest is an essential strategy for viral survival and proliferation in the host cells. A clarification system
Mingjun Su +5 more
doaj +1 more source
Requirements for Cell Cycle Arrest by p16INK4a [PDF]
Molecular Cell, 2000 Analysis of tumor-derived mutations has led to the suggestion that p16INK4a, cyclin D1, cdk4, and the retinoblastoma protein (pRB) are components of a regulatory pathway that is inactivated in most tumor cells. Cell cycle arrest induced by p16INK4a, an inhibitor of cyclin D-dependent kinases, requires pRB, and it has been proposed that this G1 arrest ...
Bruce, Jacqueline L. +4 more
openaire +2 more sources