Results 41 to 50 of about 526,953 (308)

Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest [PDF]

The Journal of Cell Biology, 1999
Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown.
H, Fan, P A, Khavari
openaire   +2 more sources

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer. [PDF]

, 2017
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown.
Barrett, John W, Black, Morgan, Boutros, Paul C, Datti, Alessandro, Fung, Kevin, Ghasemi, Farhad, Le, Carson Cao Son Huu, Leong, Hon Sing, Lowerison, Matthew R, MacNeil, Danielle, Mymryk, Joe S, Nichols, Anthony C, Palma, David A, Pinto, Nicole, Ruicci, Kara M, Vizeacoumar, Frederick, Winquist, Eric, Yoo, John   +17 more
core   +1 more source

Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells

Biological Research, 2015
BACKGROUND: We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apoptosis in three human cancer ...
Jian-Ru Guo, Qian-Qian Chen, Christopher Wai-Kei Lam, Wei Zhang   +3 more
doaj   +1 more source

Meis1 regulates postnatal cardiomyocyte cell cycle arrest [PDF]

Nature, 2013
The neonatal mammalian heart is capable of substantial regeneration following injury through cardiomyocyte proliferation. However, this regenerative capacity is lost by postnatal day 7 and the mechanisms of cardiomyocyte cell cycle arrest remain unclear.
Mahmoud, Ahmed I., Kocabas, Fatih, Muralidhar, Shalini A., Kimura, Wataru, Koura, Ahmed S., Thet, Suwannee, Porrello, Enzo R., Sadek, Hesham A.   +7 more
openaire   +3 more sources

The properties of nerve cell precursors in hydra [PDF]

, 1986
Two signals, the head activator and an injury stimulus, control differentiation of nerve cells from uncommitted stem cells in hydra [Th. Holstein, H. C. Schaller, and C. N. David, (1986) Dev. Biol. 115, 9–17].
David, Charles N., Holstein, Thomas W.
core   +1 more source

Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

eLife
Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a single irreparable DSB is sufficient to activate the DDC and induce cell cycle arrest
Felix Y Zhou, David P Waterman, Marissa Ashton, Suhaily Caban-Penix, Gonen Memisoglu, Vinay V Eapen, James E Haber   +6 more
doaj   +1 more source

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

PLoS ONE, 2009
BackgroundThe African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Terry K Smith, Nadina Vasileva, Eva Gluenz, Stephen Terry, Neil Portman, Susanne Kramer, Mark Carrington, Shulamit Michaeli, Keith Gull, Gloria Rudenko   +9 more
doaj   +1 more source

Synthesis of Combretastatin A-4 and 3 0 -Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression [PDF]

, 2020
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3 0 -aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities.
Agut, Raúl, Carda, Miguel, Falomir, Eva, Gil Edo, Raquel, Marco, J. Alberto, Martín Beltrán, Celia, Murga, Juan, Pla, Alberto   +7 more
core   +1 more source

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs [PDF]

, 2012
Background: Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 50-deoxy-5-fluorouridine (50-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin 3 along with other p53 ...
Casado, Javier (Casado Merediz), Molina Arcas, Míriam, Pastor Anglada, Marçal, Pérez Torras, Sandra, Trigueros Motos, Laia   +4 more
core   +1 more source

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source