Results 51 to 60 of about 6,610,084 (246)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs

, 2017
© 2017 Taylor & Francis. Defining the roadblocks responsible for cell cycle arrest in adult cardiomyocytes lies at the core of developing cardiac regenerative therapies. p53 and Mdm2 are crucial mediators of cell cycle arrest in proliferative cell types,
Filio Billia, Aschar-Sobbi, Roozbeh, Grothe, Daniela, Billia, Filio, Ludger Hauck, Butany, Jagdish, Beca, Sanja, Tak W. Mak, Roozbeh Aschar-Sobbi, Hauck, Ludger, Daniela Grothe, Stanley-Hasnain, Shanna, Backx, Peter H., Shanna Stanley-Hasnain, Peter H. Backx, Sanja Beca, Mak, Tak W., Jagdish Butany   +17 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition

Haematologica, 2018
Chemotherapeutic agents, e.g., cytarabine and doxorubicin, cause DNA damage. However, it remains unknown whether such agents differentially regulate cell cycle arrest in distinct types of B-cell lymphomas, and whether this phenotype can be exploited for ...
Xiaoguang Wang, Zhangguo Chen, Ameet K. Mishra, Alexa Silva, Wenhua Ren, Zenggang Pan, Jing H. Wang   +6 more
doaj   +1 more source

The role of anchorage in cell cycle control [PDF]

, 2009
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint ...
Cremona, C.A.
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dillenia Suffruticosa Extract Inhibits Proliferation of Human Breast Cancer Cell Lines (MCF-7 and MDA-MB-231) via Induction of G2/M Arrest and Apoptosis

Molecules, 2013
The present research was designed to evaluate the anticancer properties of Dillenia suffruticosa extract. Our focus was on the mode of cell death and cell cycle arrest induced in breast cancer cells by the active fractions (designated as D/F4, D/F5 and ...
Maznah Ismail, Norsharina Ismail, Yim Sim Tor, Nurshafini Ishak, Jhi Biau Foo, Intan Safinar Ismail, Latifah Saiful Yazan, Nurdin Armania   +7 more
doaj   +1 more source

JSI-124 Induces Cell Cycle Arrest and Regulates the Apoptosis in Glioblastoma Cells

Biomedicines, 2023
Cucurbitacin I (JSI-124), derived from Cucurbitaceae, has shown the potential to induce apoptosis and cell cycle arrest in some cancer cells. However, the effect of JSI-124 on glioblastoma multiforme (GBM) cell cycle and apoptosis is still unclear.
Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu   +2 more
doaj   +1 more source

Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells [PDF]

Journal of Cell Biology, 2010
In most lineages, cell cycle exit is correlated with the growth of a primary cilium. We analyzed cell cycle exit and ciliogenesis in human retinal cells and found that, contrary to the classical view, not all cells exiting the cell division cycle generate a primary cilium.
Pitaval, Amandine, Tseng, Qingzong, Bornens, Michel, Thery, Manuel   +3 more
openaire   +3 more sources

Cell arrest and cell death in mammalian preimplantation development [PDF]

, 2011
The causes, modes, biological role and prospective significance of cell death in preimplantation development in humans and other mammals are still poorly understood.
Tuna Güngör, Eckhard Wolf, Güngör Tuna, Horst-Dieter Reichenbach, Leidenfrost, Sandra, Reichenbach, Myriam, Reichenbach Myriam, Leidenfrost Sandra, Reichenbach, Horst-Dieter, Myriam Reichenbach, Sandra Leidenfrost, Marc Boelhauve, Fred Sinowatz, Habermann, Felix A., Felix A Habermann, Wolf Eckhard, Felix A. Habermann, Boelhauve, Marc, Güngör, Tuna, Boelhauve Marc, Wolf, Eckhard, Sinowatz, Fred, Reichenbach Horst-Dieter, Sinowatz Fred, Habermann Felix A.   +24 more
core   +2 more sources