Results 31 to 40 of about 526,953 (308)
RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light [PDF]
, 2009 In nature, organisms are exposed to chronic low- dose ultraviolet light ( CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA
Carr, Antony M +3 more
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Requirements for Cell Cycle Arrest by p16INK4a [PDF]
Molecular Cell, 2000 Analysis of tumor-derived mutations has led to the suggestion that p16INK4a, cyclin D1, cdk4, and the retinoblastoma protein (pRB) are components of a regulatory pathway that is inactivated in most tumor cells. Cell cycle arrest induced by p16INK4a, an inhibitor of cyclin D-dependent kinases, requires pRB, and it has been proposed that this G1 arrest ...
Bruce, Jacqueline L. +4 more
openaire +2 more sources
Vaccinia Virus Arrests and Shifts the Cell Cycle [PDF]
Viruses, 2021 ABSTRACTModulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA damage response. However, the cellular factors and viral effectors that mediate these changes
Caroline K. Martin +6 more
openaire +5 more sources
Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core +2 more sources
Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
Cell Division, 2007 The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses.
Hara Eiji, Ohtani Naoko, Takahashi Akiko
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Hydroquinone (HQ), a well-known carcinogenic agent, induces oxidative stress, cell cycle arrest, apoptosis, and malignant transformation. As an antioxidant actor, the nuclear factor erythroid 2-related factor 2 (Nrf2) drives adaptive cellular protection ...
Lin Chen +7 more
doaj +1 more source
Synchronized Cell Cycle Arrest Promotes Osteoclast Differentiation [PDF]
International Journal of Molecular Sciences, 2016 Osteoclast progenitors undergo cell cycle arrest before differentiation into osteoclasts, induced by exposure to macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). The role of such cell cycle arrest in osteoclast differentiation has remained unclear, however.
Kwon, Minsuk +6 more
openaire +3 more sources
Role for Ceramide in Cell Cycle Arrest [PDF]
Journal of Biological Chemistry, 1995 The dependence of some cell types on serum factors for growth may represent a powerful, but poorly studied, model for antimitogenic pathways. In this study, we examine ceramide as a candidate intracellular mediator of serum factor dependence. In Molt-4 leukemia cells, serum withdrawal caused a significant arrest in cell cycle progression (80% of cells ...
S, Jayadev +7 more
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ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair [PDF]
, 2008 Background: The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the resistant cell lines have a cell
A Husain +43 more
core +2 more sources
Microarray analysis of cell cycle gene expression in adult human corneal endothelial cells. [PDF]
PLoS ONE, 2014 Corneal endothelial cells (ECs) form a monolayer that controls the hydration of the cornea and thus its transparency. Their almost nil proliferative status in humans is responsible, in several frequent diseases, for cell pool attrition that leads to ...
Binh Minh Ha Thi +11 more
doaj +1 more source